Evidence map›Paper›PMID 36006966›Full record

ArticlePloS one2022

Molecular and spatial epidemiology of HCV among people who inject drugs in Boston, Massachusetts.

Thomas J Stopka, Omar Yaghi, Min Li, Elijah Paintsil, Kenneth Chui, David Landy, Robert Heimer

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas J StopkaDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, United States of America.
Omar YaghiDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, United States of America.ORCID 0000-0002-5541-3182
Min LiYale University School of Medicine, New Haven, CT, United States of America.
Elijah PaintsilYale University School of Medicine, New Haven, CT, United States of America.
Kenneth ChuiDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, United States of America.
David LandyDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, United States of America.
Robert HeimerYale University School of Medicine, New Haven, CT, United States of America.ORCID 0000-0003-0589-6697

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Parenteral HCV Transmission: Assessing Risks and Prevention Strategies in vitroR01DA030420 · NIDA · YALE UNIVERSITY · PI ABDALA, NADIA · 2011 to 2015
$2.3M
NIAID NIH HHS P30 AI042853NIDA NIH HHS R01 DA030420
6 · The paper itself

Abstract

Integration of genetic, social network, and spatial data has the potential to improve understanding of transmission dynamics in established HCV epidemics. Sequence data were analyzed from 63 viremic people who inject drugs recruited in the Boston area through chain referral or time-location sampling. HCV subtype 1a was most prevalent (57.1%), followed by subtype 3a (33.9%). The phylogenetic distances between sequences were no shorter comparing individuals within versus across networks, nor by location or time of first injection. Social and spatial networks, while interesting, may be too ephemeral to inform transmission dynamics when the date and location of infection are indeterminate.

Indexed as

Drug UsersHepatitis CSubstance Abuse, IntravenousBostonHepacivirusHumansMassachusettsMolecular EpidemiologyPhylogeny

Identifiers

PMID36006966
PMCPMC9409531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.