ArticleIEEE transactions on bio-medical engineering2023
Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs With Spontaneously Occurring Soft Tissue Sarcomas.
Article in IEEE transactions on bio-medical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Investigation of High Pulse Repetition Frequency Single-Cycle Histotripsy for Rapid Tissue Ablation.Ultrasound in medicine & biology · 2026Article
- Characterization of Bubble Cloud Formation and Tissue Ablation Using a High-Frequency Endoscopic Histotripsy System.Ultrasound in medicine & biology · 2026Article
- Ultrasound-Guided Histotripsy for Non-Invasive Treatment of Ex Vivo Soft Tissue Tumors: Preclinical Feasibility Study.Annals of surgical oncology · 2026Article
- Engineering the tumor immune landscape: Translating non-invasive physical stimulation into tumor-associated macrophage-targeted cancer immunotherapy.Bioengineering & translational medicine · 2026Review
- Pilot Study of Partial Tumor Ablation Using Thermal High-Intensity Focused Ultrasound (HIFU) in Feline Soft Tissue Sarcomas.Animals : an open access journal from MDPI · 2026Article
- The first limb-sparing use of histotripsy for canine osteosarcoma.Scientific reports · 2026Article
- Histotripsy treatment reduces tumor burden and extends survival in an orthotopic mouse model of osteosarcoma.Frontiers in oncology · 2026Article
- Understanding histotripsy ablation safety: a systematic review of pre-clinical and clinical adverse events.CVIR oncology · 2026Review
- MRI for the Assessment of Histotripsy Ablation in a Canine Osteosarcoma Comparative Oncology Model.Ultrasound in medicine & biology · 2026Article
- Non-Invasive Pancreas Ablation Using Histotripsy: Pre-clinical Safety Study in an In Vivo Porcine Model.Ultrasound in medicine & biology · 2026Article
- Focused Ultrasound for Sarcomas: A Narrative Review.Current oncology (Toronto, Ont.) · 2025Review
- Review
- Assessment of histotripsy as a bone-sparing tumor ablation technique inFrontiers in veterinary science · 2025Article
- Article
- Advances in Tumor Management: Harnessing the Potential of Histotripsy.Radiology. Imaging cancer · 2024Review
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Inhibitory checkpoint molecule mRNA expression in canine soft tissue sarcoma.Veterinary and comparative oncology · 2023Article
- Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma Model.Biomedicines · 2023Article
- Surgical Management of Brain Tumors with Focused Ultrasound.Current oncology (Toronto, Ont.) · 2023Review
- Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs.Cancers · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
introductionHistotripsy is a non-invasive focused ultrasound therapy that uses controlled acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports investigating histotripsy for the treatment of soft tissue sarcoma (STS).
objectiveThis study aimed to investigate the in vivo feasibility of ablating STS with histotripsy and to characterize the impact of partial histotripsy ablation on the acute immunologic response in canine patients with spontaneous STS.
methodsA custom 500 kHz histotripsy system was used to treat ten dogs with naturally occurring STS. Four to six days after histotripsy, tumors were surgically resected. Safety was determined by monitoring vital signs during treatment and post-treatment physical examinations, routine lab work, and owners' reports. Ablation was characterized using radiologic and histopathologic analyses. Systemic immunological impact was evaluated by measuring changes in cytokine concentrations, and tumor microenvironment changes were evaluated by characterizing changes in infiltration with tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) using multiplex immunohistochemistry and differential gene expression.
resultsResults showed histotripsy ablation was achievable and well-tolerated in all ten dogs. Immunological results showed histotripsy induced pro-inflammatory changes in the tumor microenvironment. Conclusion & Significance: Overall, this study demonstrates histotripsy's potential as a precise, non-invasive treatment for STS.
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Registered trials
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