ArticleTomography (Ann Arbor, Mich.)2022
Peritumoral Brain Edema in Relation to Tumor Size Is a Variable That Influences the Risk of Recurrence in Intracranial Meningiomas.
Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Epidemiology, characteristics, and prognostic factors of lymphoplasmacyte-rich meningioma: a systematic literature review.BMC cancer · 2024Pooled it
- FOXC1 as a molecular predictor of postoperative peritumoral edema resolution in meningiomas.Journal of neuro-oncology · 2026Article
- Artificial Intelligence-Based MRI Segmentation in Glioblastoma and Single Brain Metastasis: An Exploratory Study of Diagnostic and Prognostic Value.Life (Basel, Switzerland) · 2026Article
- Characteristics of Brain Metastases Identified by PET-CT Imaging in Patients with Lung Cancer.Noro psikiyatri arsivi · 2026Article
- Topological feature-driven TabPFN model for prediction of enlarged hemorrhage and edema after tumor resection in meningiomas.Frontiers in medicine · 2026Article
- Impact of pre-operative edema index on surgical outcomes in supratentorial meningiomas: A retrospective analysis.Pakistan journal of medical sciences · 2025Article
- Long-term outcomes following upfront single-session gamma knife stereotactic radiosurgery for large volume meningiomas.Journal of neuro-oncology · 2025Article
- Development of a Machine Learning Algorithm for the Prediction of WHO Grade 1 Meningioma Recurrence.Cureus · 2025Article
- Exploring a recurrence model for atypical meningioma based on multiparametric MRI radiomic and clinical characteristics: a multicenter retrospective cohort study.Radiation oncology (London, England) · 2025Article
- Peritumoral Edema in Canine Extra-Axial Brain Tumours: Effect of Steroids.Veterinary and comparative oncology · 2025Article
- Impact of 2021 World Health Organization Grading, Peritumoral Edema, and Radiotherapy on the Recurrence of a Grossly Resected Intracranial Meningiomas: A Ten-Year Follow-Up Study.World journal of oncology · 2025Article
- Primary Extradural Meningioma: A Systematic Review of Diagnostic Features, Clinical Management, and Surgical Outcomes.Cancers · 2024Review
- Article
- Preoperative executive functioning impairments in patients with a meningioma: does a frontal location matter?Brain imaging and behavior · 2024Article
- Topographic Patterns of Intracranial Meningioma Recurrences-Systematic Review with Clinical Implication.Cancers · 2024Review
- Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence.Cancers · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peritumoral brain edema (PBE) is common in intracranial meningiomas (IM) and can increase their morbidity. It is not uncommon for a neurosurgeon to confront meningiomas with a large proportion of PBE independently from the site and size of the contrast-enhancing lesion with increased surgical risks. We performed a retrospective review of 216 surgically-treated patients suffering from IM. We recorded clinical, biological, and radiological data based on the rate of tumor and edema volume and divided the patients into a group with high Edema/Tumor ratio and a group with a low ratio. We investigated how the ratio of edema/lesion may affect the outcome. Multivariate analysis was performed for the two groups. Smokers were found to be more likely to belong to the high-rate group. The edema/tumor ratio did not affect the surgical radicality; however, independently of the biological sub-type, WHO grading, and EOR, a higher frequency of recurrence is shown in patients with a high edema/tumor ratio (70.5% vs. 8.4%. p < 0.01). There is evidence to suggest that the blood-brain barrier (BBB) damage from smoke could play a role in an increased volume of PBE. The present study demonstrates that IMs showing a high PBE ratio to tumor volume at diagnosis are associated with a smoking habit and a higher incidence of recurrence independently of their biological type and grading.
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Registered trials
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