Evidence map›Paper›PMID 36006020›Full record

Observational studyEuropean journal of public health2022

Associations of ultra-processed food consumption with cardiovascular disease and all-cause mortality: UK Biobank.

Xuanli Chen, Jiadong Chu, Wei Hu, Na Sun, Qida He, Siyuan Liu, Zhaolong Feng, Tongxing Li, Qiang Han, Yueping Shen

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xuanli ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0003-0317-4623
Jiadong ChuDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Wei HuDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Na SunDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Qida HeDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Siyuan LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Zhaolong FengDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Tongxing LiDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Qiang HanDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Yueping ShenDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
Soochow University · CN

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the associations between ultra-processed food (UPF) consumption and the risk of cardiovascular disease and all-cause mortality in the UK Biobank Cohort.

methodsThis observational prospective study evaluated 60 298 participants aged 40 years or older. We used the NOVA classification system to identify and categorize UPF. The associations among UPF consumption, cardiovascular disease (CVD) incidence and all-cause mortality were estimated using multivariable Cox proportional hazards models. Dose-response analysis of UPF consumption and CVD incidence and mortality was performed using a restricted cubic spline.

resultsAfter a median follow-up of 10.9 years, 6048 participants (10.0%) experienced CVD events, and 5327 (8.8%) and 1503 (2.5%) experienced coronary heart and cerebrovascular diseases, respectively. There were 2590 (4.3%) deaths, of which 384 (0.6%) deaths were caused by CVD. A higher intake of UPF was associated with a higher risk of CVD and all-cause mortality (all P < 0.001). A higher intake of UPF was associated with a higher risk of CVD [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.09-1.26], coronary heart disease (HR = 1.16, 95% CI: 1.07-1.25), cerebrovascular disease (HR = 1.30, 95% CI: 1.13-1.50) and all-cause mortality (HR = 1.22, 95% CI: 1.09-1.36). The association of UPF consumption with a range of CVD incidents and all-cause mortality was monotonic (all P for non-linearity > 0.30).

conclusionsA higher proportion of UPF consumption was associated with CVD and all-cause mortality. Thus, actions to limit UPF consumption should be incorporated into the CVD and all-cause mortality prevention recommendations.

Indexed as

Cardiovascular DiseasesBiological Specimen BanksDietFast FoodsHumansProspective StudiesRisk FactorsUnited Kingdom

Identifiers

PMID36006020
PMCPMC9527958
OpenAlexW4293092489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.