ArticleMagnetic resonance in medicine2022
Identification of l-Tryptophan by down-field
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Exploring the acute and chronic effects of a multistrain probiotic supplement on cognitive function and mood in healthy older adults: a randomized controlled trial.The American journal of clinical nutrition · 2025Trial
- Downfield magnetic resonance signals serve as endogenous imaging biomarkers of nucleotide metabolism in glioma.Communications biology · 2026Article
- Quantification of Tryptophan and NADMagnetic resonance in medicine · 2026Article
- Amide mapping in the human brain using downfield MRSI at 3 T and 7 T.Magnetic resonance in medicine · 2025Article
- Optimization ofMagnetic resonance in medicine · 2025Article
- High-field downfield MR spectroscopic imaging in the human brain.Magnetic resonance in medicine · 2024Article
- Optimization ofmedRxiv : the preprint server for health sciences · 2024Article
- Downfield proton MRSI with whole-brain coverage at 3T.Magnetic resonance in medicine · 2023Article
- Identification of new resonances in downfieldMagnetic resonance in medicine · 2023Article
- Article
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8 authors.
Funding
Abstract
purposeTo explore the presence of new resonances beyond 9.4 ppm from the human brain, down-field proton MRS was performed in vivo in the human brain on 6 healthy volunteers at 7 T.
methodsTo maximize the SNR, a large voxel was placed within the brain to cover the maximal area in such a way that sinus cavities were avoided. A spectrally selective 90° E-BURP pulse with an excitation bandwidth of 2 ppm was used to probe the spectral chemical shift range between 9.1 and 10.5 ppm. The E-BURP pulse was integrated with PRESS spatial localization to obtain non-water-suppressed proton MR spectra from the desired spectral region.
resultsIn the down-field proton MRS obtained from all of the volunteers scanned, we identified a new peak consistently resonating at 10.1 ppm. Protons associated with this resonance are in cross-relaxation with the bulk water, as demonstrated by the water saturation and deuterium exchange experiments.
conclusionBased on the chemical shift, this new peak was identified as the indole (-NH) proton of l-tryptophan (l-TRP) and was further confirmed from phantom experiments on l-TRP. These promising preliminary results potentially pave the way to investigate the role of cerebral metabolism of l-TRP in healthy and disease conditions.
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