ArticleMetabolites2022
The PROVIT Study-Effects of Multispecies Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder-A Randomized, Placebo-Controlled Trial.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03300440 (The Influence of Probiotics on Body and Mind in Individuals With Psychiatric Disorders - a Clinical Study), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Probiotics on Body and Mind in Individuals With Psychiatric Disorders - a Clinical Study
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis.Molecular psychiatry · 2026Pooled it
- Alterations of short-chain fatty acids in depression and effects of probiotics/prebiotics interventions on levels and clinical symptoms: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- The therapeutic readiness of probiotics in major depressive disorder: A systematic review of randomised controlled trials.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- Efficacy of probiotic intervention in unmedicated depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials.Nutrients · 2024Pooled it
- Effect of Probiotic Supplementation on Gut Microbiota in Patients with Major Depressive Disorders: A Systematic Review.Nutrients · 2023Pooled it
- Trial
- PROVIT-CLOCK: A Potential Influence of Probiotics and Vitamin B7 Add-On Treatment and Metabolites on Clock Gene Expression in Major Depression.Neuropsychobiology · 2024Trial
- Evaluating the causal effects of circulating metabolites on major depression disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Clinical and Mechanistic Association Between Intestinal Permeability and the Gut Microbiome in Cirrhosis: Role of Phascolarctobacterium.United European gastroenterology journal · 2026Article
- Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response.Molecular psychiatry · 2026Review
- Brain-gut-microbiota axis: a review on the bidirectional regulatory mechanisms between gut microbiota and brain and their disease interactions.Frontiers in microbiology · 2026Review
- Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities.Gut microbes · 2025Review
- Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis.Molecular neurobiology · 2025Review
- Transforming mental health: the future of personalized psychobiotics in anxiety and depression therapy.Frontiers in neuroscience · 2025Article
- Nitrogen recycling by the gut microbiome in sarcopenia.Frontiers in microbiology · 2025Article
- Strain-specific effects of probiotics on depression and anxiety: a meta-analysis.Gut pathogens · 2024Article
- The gut microbiota-brain axis in neurological disorders.MedComm · 2024Review
- Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area.Microbiology spectrum · 2024Article
- Depression and the Aberrant Intestinal Microbiome.Gastroenterology & hepatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 3 institutions in 2 countries.
Kathrin KreuzerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-3969-6378
Alexandra ReiterPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Anna Maria Birkl-TöglhoferNeuropathology and Molecular Pathology, Institute for Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6908-145X
Nina DalknerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-7716-3674
Sabrina MörklPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5034-6358
Marco MairingerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-9564-8835
Eva FleischmannPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-0459-6553
Frederike FellendorfPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-7215-3848
Martina PlatzerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Melanie LengerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Tanja FärberInstitute for Psychology, Otto Friedrich University of Bamberg, 96047 Bamberg, Germany.ORCID 0000-0003-4576-682X
Matthias SeidlPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Armin BirnerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Robert QueissnerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Lilli-Marie Stefanie MendelPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Alexander MagetPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Alexandra Kohlhammer-DohrPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Alfred HäusslPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-9623-8707
Jolana Wagner-SkacelPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Helmut SchögglPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Daniela Amberger-OttiPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Annemarie PainoldPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-7372-8655
Theresa Lahousen-LuxenbergerPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Brigitta Leitner-AfscharPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Johannes HaybaeckNeuropathology and Molecular Pathology, Institute for Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Hansjörg HabischResearch Unit Integrative Structural Biology, Division for Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5537-506X
Tobias MadlResearch Unit Integrative Structural Biology, Division for Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-9725-5231
Eva ReininghausPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5964-4087
Susanne BengesserPsychosomatics and Psychotherapy Clinical Department of Psychiatry and Psychotherapeutic Medicine, University Hospital for Psychiatry, Medical University of Graz, 8036 Graz, Austria.
Medical University of Graz · ATInnsbruck Medical University · ATUniversity of Bamberg · DE
Funding
Austrian Research Promotion Agency 864690Austrian Research Promotion Agency 870454Austrian Science Fund FWF I 3792Austrian Science Fund FWF P 28854Austrian Science Fund FWF W 1226FWF Austrian Science Fund DK-MCD W1226FWF Austrian Science Fund DOC-130FWF Austrian Science Fund I3792FWF Austrian Science Fund KLI 986FWF Austrian Science Fund P28854Swiss National Science Foundation 32003B_159518/1
Abstract
The gut-brain axis plays a role in major depressive disorder (MDD). Gut-bacterial metabolites are suspected to reduce low-grade inflammation and influence brain function. Nevertheless, randomized, placebo-controlled probiotic intervention studies investigating metabolomic changes in patients with MDD are scarce. The PROVIT study (registered at clinicaltrials.com NCT03300440) aims to close this scientific gap. PROVIT was conducted as a randomized, single-center, double-blind, placebo-controlled multispecies probiotic intervention study in individuals with MDD (
Indexed as
butyratedepressiongut–brain-axismetabolomicsNMR spectroscopyprobioticsrandomized controlled trial
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT03300440ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.