Evidence map›Paper›PMID 36005609›Full record

ArticleMetabolites2022

Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass.

Tiffany S Ko, Constantine D Mavroudis, Emilie J Benson, Rodrigo M Forti, Richard W Melchior, Timothy W Boorady, Vincent C Morano, Kobina Mensah-Brown, Yuxi Lin, Danielle Aronowitz and 11 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Tiffany S KoDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-5113-0310
Constantine D MavroudisDivision of Cardiothoracic Surgery, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Emilie J BensonDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rodrigo M FortiDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-8978-2525
Richard W MelchiorDivision of Perfusion Services, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Timothy W BooradyGeisinger Commonwealth School of Medicine, Scranton, PA 18510, USA.
Vincent C MoranoDepartment of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218, USA.
Kobina Mensah-BrownPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yuxi LinDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Danielle AronowitzDivision of Cardiothoracic Surgery, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-0043-8558
Jonathan P StarrDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Tami M RosenthalDivision of Perfusion Services, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Brandon C ShadeDivision of Perfusion Services, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-3033-9016
Kellie L SchiavoDivision of Perfusion Services, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Brian R WhiteDepartment of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-5196-2339
Jennifer M LynchDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
J William GaynorDivision of Cardiothoracic Surgery, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Daniel J LichtDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wesley B BakerDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USGeisinger Commonwealth School of Medicine · USJohns Hopkins University · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeR01HL141386 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KILBAUGH, TODD JUSTEN · 2019 to 2023
$4.4M
Diffuse Optics for Pediatric Hydrocephalus ManagementR01NS113945 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI BAKER, WESLEY · 2020 to 2024
$1.9M
Optical Functional Neuroimaging of Acute and Chronic HypoxiaK08NS117897 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WHITE, BRIAN RICHARD · 2020 to 2024
$843k
Functional Diffuse Optical Measurements of Psychomotor Function in Neonates with Hypoplastic Left Heart Syndrome (HLHS)F31HD085731 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI KO, TIFFANY S · 2016 to 2019
$133k
Children's Hospital of Philadelphia Cardiac CenterChildren's Hospital of Philadelphia Frontier ProgramNHLBI NIH HHS R01 HL141386NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NICHD NIH HHS F31 HD085731NIH HHS F31-HD085731NIH HHS K08-NS117897NIH HHS P41-EB015893NIH HHS R01-HL141386NIH HHS R01-NS060653NIH HHS R01-NS113945NIH HHS T32-HL007915NINDS NIH HHS K08 NS117897NINDS NIH HHS R01 NS060653NINDS NIH HHS R01 NS113945
6 · The paper itself

Abstract

Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair. Here, we investigate correlations between non-invasive optical neuromonitoring of cerebral hemodynamics, which has recently shown promise for the prediction of postoperative white matter injury in this patient population, and invasive cerebral microdialysis biomarkers. We compared cerebral tissue oxygen saturation (StO

Indexed as

cardiopulmonary bypasscerebral hemodynamicscerebral microdialysiscongenital heart surgerydeep hypothermic circulatory arrestdiffuse opticshypoxic-ischemianeuromonitoring

Identifiers

PMID36005609
PMCPMC9416552
OpenAlexW4293104736

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.