Evidence map›Paper›PMID 36005582›Full record

ArticleMetabolites2022

Metabolism of Exogenous [2,4-

Susanna Scafidi, Jennifer Jernberg, Gary Fiskum, Mary C McKenna

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Tissue specific roles of fatty acid oxidation.Advances in biological regulation · 2025
    Review
  5. Article
  6. Article
  7. Neuroprotective effects of lactate and ketone bodies in acute brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  8. Tracing the path of disruption:CNS neuroscience & therapeutics · 2024
    Review
  9. Review
  10. Nature biomedical engineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Susanna ScafidiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jennifer JernbergDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Gary FiskumDepartment of Anesthesiology, Center for Shock Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mary C McKennaDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5236-3853
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

SPECTRIN-DEPENDENT MEMBRANE DOMAINS IN THE DEVELOPING CNSP01HD016596 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI MCKENNA, MARY C · 1985 to 2013
$12.8M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Project IV- Cerebellar Function After Hypoxia-Ischemia and Precipitating InflammationP01HD085928 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BEARER, CYNTHIA FRANCES, MCCARTHY, MARGARET M. · 2016 to 2020
$6.3M
Role of fatty acid oxidation after pediatric head injuryR01NS110808 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCAFIDI, SUSANNA · 2019 to 2023
$1.8M
Mechanisms of metabolic adaptation after traumatic brain injuryR01NS111230 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCAFIDI, SUSANNA · 2019 to 2023
$1.8M
Metabolic Dysfunction and Neuroprotection after Pediatric Head InjuryK08NS069815 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SCAFIDI, SUSANNA · 2011 to 2015
$918k
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5-P01 HD016596NICHD NIH HHS P01 HD016596NICHD NIH HHS P01 HD085928NICHD NIH HHS P50 HD103538NINDS NIH HHS 1R01 NS110808NINDS NIH HHS K08 NS069815NINDS NIH HHS R01 NS110808NINDS NIH HHS R01 NS111230
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is leading cause of morbidity in young children. Acute dysregulation of oxidative glucose metabolism within the first hours after injury is a hallmark of TBI. The developing brain relies on ketones as well as glucose for energy. Thus, the aim of this study was to determine the metabolism of ketones early after TBI injury in the developing brain. Following the controlled cortical impact injury model of TBI, 21-22-day-old rats were infused with [2,4-

Indexed as

developing brainketone bodiesmetabolismtraumatic brain injuryβ-hydroxybutyrate

Identifiers

PMID36005582
PMCPMC9414923
OpenAlexW4289176437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.