Evidence map›Paper›PMID 36005521›Full record

ArticleMarine drugs2022

Antibacterial and Anticancer Activities of Pleurocidin-Amide, a Potent Marine Antimicrobial Peptide Derived from Winter Flounder,

Hui-Chen Hsu, Ming-Hsin Chen, Ming-Lung Yeh, Wei-Jung Chen

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  9. Bioactive Peptides from Marine Organisms.Protein and peptide letters · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hui-Chen HsuDepartment of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.
Ming-Hsin ChenDepartment of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.
Ming-Lung YehDepartment of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.
Wei-Jung ChenDepartment of Biotechnology and Animal Science, National Ilan University, Yilan 26047, Taiwan.ORCID 0000-0001-7489-1019
National Ilan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 104-2313-B-197-002-MY3, MOST 102-2311-B-197-001 and MOST 101-2311-B-197-001
6 · The paper itself

Abstract

The extensive use of conventional antibiotics has led to the growing emergence of many resistant strains of pathogenic bacteria. Evidence suggests that cationic antimicrobial peptides (AMPs) have the greatest potential to serve as traditional antibiotic substitutes. Recent studies have also reported that certain AMPs have selective toxicity toward various types of cancer cells. The electrostatic attraction between the negatively charged membrane components and AMPs is believed to play a crucial role in the disruption of bacterial and cancer cell membranes. In the current study, we used a potent AMP called Pleurocidin (Ple) derived from winter flounder

Indexed as

FlounderAmidesAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacteriaEscherichia coliFish ProteinsGram-Negative BacteriaGram-Positive BacteriaHumansMiceMicrobial Sensitivity TestsAmidesAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesFish Proteinspleurocidinantibacterialanticancerantimicrobial peptide (AMP)multidrug resistance (MDR)non-small cell lung adenocarcinomaPleurocidin (Ple)

Identifiers

PMID36005521
PMCPMC9409841
OpenAlexW4291449816

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.