Evidence map›Paper›PMID 36005493›Full record

ArticleMarine drugs2022

Antioxidant Activity of Fucoidan Modified with Gallic Acid Using the Redox Method.

Keylla Dayanne Coelho Marinho de Melo, Lucas Dos Santos Lisboa, Moacir Fernandes Queiroz, Weslley Souza Paiva, Ana Carolina Luchiari, Rafael Barros Gomes Camara, Leandro Silva Costa, Hugo Alexandre Oliveira Rocha

Abstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Osteoprotective Activity ofAntioxidants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Fucoidan fromBiomedicines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keylla Dayanne Coelho Marinho de MeloPostgraduate Programe Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal 59.078-970, RN, Brazil.ORCID 0000-0002-2345-8108
Lucas Dos Santos LisboaDepartment of Biochemistry, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Moacir Fernandes QueirozDepartment of Biochemistry, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.ORCID 0000-0003-4338-6882
Weslley Souza PaivaDepartment of Biochemistry, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.ORCID 0000-0002-2022-5659
Ana Carolina LuchiariLaboratory of Ornamental Fish, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Rafael Barros Gomes CamaraDepartment of Biochemistry, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.ORCID 0000-0001-5109-1991
Leandro Silva CostaFederal Institute of Education, Science and Technology of Rio Grande do Norte, Canguaretama 59.190-000, RN, Brazil.
Hugo Alexandre Oliveira RochaPostgraduate Programe Health Sciences, Federal University of Rio Grande do Norte (UFRN), Natal 59.078-970, RN, Brazil.ORCID 0000-0003-2252-1221

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior AUXPE-CIMAR-1956/2014National Council for Scientific and Technological Development n° 408369/2016-7
6 · The paper itself

Abstract

Antioxidant compounds decrease the amount of intracellular reactive oxygen species (ROS) and, consequently, reduce the deleterious effects of ROS in osteoblasts. Here, we modified a 21 kDa fucoidan (FucA) with gallic acid (GA) using the redox method, to potentiate its antioxidant/protective capacity on pre-osteoblast-like cells (MC3T3) against oxidative stress. The 20 kDa FucA-GA contains 37 ± 3.0 mg GA per gram of FucA. FucA-GA was the most efficient antioxidant agent in terms of total antioxidant capacity (2.5 times), reducing power (five times), copper chelation (three times), and superoxide radical scavenging (2 times). Exposure of MC3T3 cells to H

Indexed as

AntioxidantsGallic AcidAnimalsHydrogen PeroxideOxidation-ReductionOxidative StressPolysaccharidesReactive Oxygen SpeciesAntioxidantsfucoidanGallic AcidHydrogen PeroxidePolysaccharidesReactive Oxygen Speciesantioxidant activityoxidative damagesulfated fucansulfated polysaccharides

Identifiers

PMID36005493
PMCPMC9410456

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.