Evidence map›Paper›PMID 36005485›Full record

ArticleMarine drugs2022

Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells.

Sukanya Unson, Tung-Cheng Chang, Yung-Ning Yang, Shwu-Huey Wang, Chi-Hung Huang, Dana R Crawford, Haw-Ming Huang, Zi-Lin Li, Hung-Yun Lin, Jacqueline Whang-Peng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Integrin αvβ3 is a Potential Therapeutic Target in Cholangiocarcinoma.International journal of medical sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Sukanya UnsonGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Tung-Cheng ChangDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang Ho Hospital, Taipei 11031, Taiwan.
Yung-Ning YangSchool of Medicine, I-Shou University and Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan.
Shwu-Huey WangCore Facility Center, Department of Research Development, Taipei Medical University, Taipei 11031, Taiwan.
Chi-Hung HuangDivision of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei 10630, Taiwan.
Dana R CrawfordDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
Haw-Ming HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-4184-3744
Zi-Lin LiGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Hung-Yun LinGraduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Jacqueline Whang-PengCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
Kuan WangGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Paul J DavisPharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.ORCID 0000-0002-6794-4917
Wen-Shan LiLaboratory of Chemical Biology and Medicinal Chemistry, Institute of Chemistry, Academia Sinica, Taipei 10617, Taiwan.ORCID 0000-0002-8359-4582
Taipei Medical University · TWAlbany College of Pharmacy and Health Sciences · USAlbany Medical Center Hospital · USCathay General Hospital · TWI-Shou University · TWNational Sun Yat-sen University · TWTaipei Medical University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWWan Fang Hospital · TW

Funding

Ministry of Science and Technology of the People's Republic of China 110-2314-B-038-114Ministry of Science and Technology of the People's Republic of China 110-2314-B-038-115Ministry of Science and Technology of the People's Republic of China 110-2314-B-038-119
6 · The paper itself

Abstract

Overexpressed EGFR and mutant

Indexed as

Colorectal NeoplasmsThyroxineB7-H1 AntigenCell Line, TumorCell ProliferationErbB ReceptorsHumansMutationProto-Oncogene Proteins p21(ras)Signal TransductionTerpenesB7-H1 AntigenEGFR protein, humanErbB ReceptorsheteroneminProto-Oncogene Proteins p21(ras)Terpenestetraiodothyroacetic acidThyroxinecolorectal cancerEGFR signalingheteroneminKRAStetrac

Identifiers

PMID36005485
PMCPMC9410344
OpenAlexW4288081142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.