Evidence map›Paper›PMID 36005424›Full record

ReviewJournal of cardiovascular development and disease2022

Pregnancy Considerations in the Multidisciplinary Care of Patients with Pulmonary Arterial Hypertension.

Julie Coursen, Catherine E Simpson, Monica Mukherjee, Arthur J Vaught, Shelby Kutty, Tala K Al-Talib, Malissa J Wood, Nandita S Scott, Stephen C Mathai, Garima Sharma

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Management of Pulmonary Hypertension in Pregnancy.Current heart failure reports · 2025
    Review
  6. Observational
  7. Review
  8. Exploring the patient perspective in pulmonary hypertension.The European respiratory journal · 2024
    Article
  9. Review
  10. Epoprostenol Exposure During Pregnancy.Critical care explorations · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Julie CoursenDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Catherine E SimpsonDivisions of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Monica MukherjeeDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Arthur J VaughtDivision of Maternal Fetal Medicine, Department of Gynecology Obstetrics, Johns Hopkins University, Baltimore, MD 21218, USA.
Shelby KuttyDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Tala K Al-TalibDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Malissa J WoodDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Nandita S ScottDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Stephen C MathaiDivisions of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Garima SharmaDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · USMassachusetts General Hospital · US

Funding

The role of xanthine oxidoreductase activity and altered metabolism in scleroderma-associated pulmonary arterial hypertensionK23HL153781 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIMPSON, CATHERINE · 2020 to 2024
$883k
NHLBI NIH HHS K23 HL153781
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a vasoconstrictive disease of the distal pulmonary vasculature resulting in adverse right heart remodeling. Pregnancy in PAH patients is associated with high maternal morbidity and mortality as well as neonatal and fetal complications. Pregnancy-associated changes in the cardiovascular, pulmonary, hormonal, and thrombotic systems challenge the complex PAH physiology. Due to the high risks, patients with PAH are currently counseled against pregnancy based on international consensus guidelines, but there are promising signs of improving outcomes, particularly for patients with mild disease. For patients who become pregnant, multidisciplinary care at a PAH specialist center is needed for peripartum monitoring, medication management, delivery, postpartum care, and complication management. Patients with PAH also require disease-specific counseling on contraception and breastfeeding. In this review, we detail the considerations for reproductive planning, pregnancy, and delivery for the multidisciplinary care of a patient with PAH.

Indexed as

cardio-obstetricsperipartum cardiovascular diseasepregnancypulmonary hypertension

Identifiers

PMID36005424
PMCPMC9409449
OpenAlexW4291016406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.