ArticleDentistry journal2022
The Correlation of Swedish Snus, Nicotine Pouches and Other Tobacco Products with Oral Mucosal Health and Salivary Biomarkers.
Article in Dentistry journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Systemic and Salivary Cytokine Levels among Adult E-Cigarette Users: A Systematic Review and Meta Analysis.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- What is the impact of nicotine pouches on oral health: a systematic review.BMC oral health · 2024Pooled it
- Oral health effects of nicotine pouches in snus users: clinical and immunological findings.Clinical oral investigations · 2026Trial
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- Tobacco-derived particulates and the periodontal axis: Distinct cytotoxic and stress-related mechanisms in human gingival fibroblasts.Scientific reports · 2026Article
- Research on the safety risk of oral nicotine products and its prospects.Current research in toxicology · 2026Review
- Review
- Self-reported oral health outcomes after switching to a novel nicotine pouch technology: a pilot study.Acta odontologica Scandinavica · 2025Observational
- Oral health effects of non-combustible nicotine products: protocol for a systematic review and network meta-analysis.Systematic reviews · 2025Article
- Investigating oral nicotine pouch use among adults in Riyadh, Saudi Arabia: prevalence, awareness, susceptibility, and associated symptoms.Frontiers in public health · 2025Article
- Oral health risks in adults who use electronic nicotine delivery systems and oral nicotine pouches: a critical review of the literature and qualitative synthesis of the available evidence.Harm reduction journal · 2024Review
- Snus Use in Adolescents: A Threat to Oral Health.Journal of clinical medicine · 2024Article
- Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes.Scientific reports · 2024Article
- Effect of conventional cigarettes and e-cigarettes on salivary biomarkers: A systematic review.Journal of advanced periodontology & implant dentistry · 2024Article
- Oral nicotine pouches with an aftertaste? Part 1: screening and initial toxicological assessment of flavorings and other ingredients.Archives of toxicology · 2023Article
- Use of New Tobacco and Nicotine Products as a Harm Reduction Strategy: A Critical Review of the Evidence.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In society, tobacco products, such as e-cigarettes, and smokeless tobacco products, such as snus and nicotine pouches, are becoming more attractive. There is still a lack of information regarding the effects of these products on the oral mucosa and oral saliva biomarkers. The aim of this study is to evaluate oral mucosa and the presence of inflammatory biomarkers IL-6, IL-1, IL-8, TNF alpha and LRG-1 in saliva. Respondents were divided in four groups based on their tobacco product usage. Oral examination was carried out, saliva samples were taken, and the detection of IL-6, IL-8, IL-1, TNF alpha and LRG-1 levels in saliva was carried out. Out of the tobacco users, 30.8% were snus users, 48.7% were cigarette users and 20.5% were e-cigarette users. The control group was composed of respondents who did not use any tobacco products. E-cigarettes were used more by women, but snus was used more by men. Mucosal changes were seen in the group of snus users, and mucosal changes were only seen in men who had used 5-10 tobacco units per day for 5-10 years. Increased IL-6 levels in saliva were detected in respondents who also experienced mucosal changes. Mucosal changes were white, leathery and localized at the site where snus sachets were placed. Saliva, as an easily available biofluid, could be used as a first tool to detect potentially precancerous signs, but the LRG1 marker cannot be used as a prognostic marker.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.