Evidence map›Paper›PMID 36005198›Full record

Observational studyCurrent oncology (Toronto, Ont.)2022

Real-World Testing Practices, Treatment Patterns and Clinical Outcomes in Patients from Central Eastern Europe with EGFR-Mutated Advanced Non-Small Cell Lung Cancer: A Retrospective Chart Review Study (REFLECT).

Urška Janžič, Nina Turnšek, Mircea Dediu, Ivan Shterev Donev, Roxana Lupu, Gabriela Teodorescu, Tudor E Ciuleanu, Adam Pluzanski

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04031898 (Real World Treatment Patterns, Clinical Outcomes and EGFR / T790M Testing Practices in EGFR-Mutated Advanced Non-Small Cell Lung Cancer Patients Receiving First-Line TKI Therapy), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04031898 completednot on this map

Real World Treatment Patterns, Clinical Outcomes and EGFR / T790M Testing Practices in EGFR-Mutated Advanced Non-Small Cell Lung Cancer Patients Receiving First-Line TKI Therapy

TypeobservationalSponsorAstraZenecaRan2019 to 2019Enrolled896ConditionsLung CancerArmsNon Interventional
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Urška JanžičMedical Oncology Department, University Clinic of Respiratory and Allergic Diseases, 4204 Golnik, Slovenia.
Nina TurnšekMedical Oncology Department, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.
Mircea DediuSanador Oncology Center, 010991 Bucharest, Romania.
Ivan Shterev DonevDepartment of Medical Oncology, MHAT Nadezhda, 1330 Sofia, Bulgaria.ORCID 0000-0003-3045-3775
Roxana LupuMedical Department, AstraZeneca Romania, 013713 Bucharest, Romania.
Gabriela TeodorescuMedical Department, AstraZeneca Romania, 013713 Bucharest, Romania.ORCID 0000-0002-2326-571X
Tudor E CiuleanuMedical Oncology Department, Oncology Institute Prof. Dr. Ion Chiricuta, 400015 Cluj-Napoca, Romania.
Adam PluzanskiLung Cancer and Chest Tumours Department, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.ORCID 0000-0002-3710-6445

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The targeted therapy with tyrosine kinase inhibitors (TKIs) against the epidermal growth factor receptor mutation (EGFRm) in advanced non-small cell lung cancer (NSCLC) changed the treatment paradigm. REFLECT study (NCT04031898) explored

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsErbB ReceptorsHumansMutationProtein Kinase InhibitorsRetrospective StudiesEGFR protein, humanErbB ReceptorsProtein Kinase Inhibitorsadvanced non-small cell lung cancerEGFR T790M mutationreal-world retrospective study

Identifiers

PMID36005198
PMCPMC9406426

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.