Evidence map›Paper›PMID 36005170›Full record

ArticleCurrent oncology (Toronto, Ont.)2022

Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer.

Makoto Kawase, Kimiaki Takagi, Kei Kawada, Takashi Ishida, Masayuki Tomioka, Torai Enomoto, Shota Fujimoto, Tomoki Taniguchi, Hiroki Ito, Koji Kameyama and 7 more

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Inflammation in Penile Squamous Cell Carcinoma: A Comprehensive Review.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Makoto KawaseDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.
Kimiaki TakagiDepartment of Urology, Daiyukai Daiichi Hospital, Ichinomiya 4918551, Japan.ORCID 0000-0003-2774-925X
Kei KawadaDepartment of Urology, Gifu Prefectural General Medical Center, Gifu 5008717, Japan.
Takashi IshidaDepartment of Urology, Gifu Municipal Hospital, Gifu 5008513, Japan.
Masayuki TomiokaDepartment of Urology, Japanese Red Cross Takayama Hospital, Takayama 5068550, Japan.
Torai EnomotoDepartment of Urology, Matsunami General Hospital, Hashima-gun 5016062, Japan.
Shota FujimotoDepartment of Urology, Ogaki Municipal Hospital, Ogaki 5038502, Japan.
Tomoki TaniguchiDepartment of Urology, Chuno Kosei Hospital, Seki 5013802, Japan.ORCID 0000-0002-2612-2191
Hiroki ItoDepartment of Urology, Toyota Memorial Hospital, Toyota 4718513, Japan.
Koji KameyamaDepartment of Urology, Central Japan International Medical Center, Minokamo 5058510, Japan.
Toru YamadaDepartment of Urology, Tokai Central Hospital, Kakamihara 5048601, Japan.
Kota KawaseDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.
Daiki KatoDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.ORCID 0000-0003-4932-0497
Manabu TakaiDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.
Koji IinumaDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.ORCID 0000-0002-0362-8624
Keita NakaneDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.
Takuya KoieDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.ORCID 0000-0002-2980-127X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-specific survival (CSS). We also identified useful predictive factors for CSS in patients with PSCC. In total, 64 patients with PSCC were enrolled. At the end of the follow-up period, 15 patients (23.4%) died owing to PSCC and six (9.4%) died owing to other causes. The 2- and 3-year CSS rates were 78.9% and 76.6%, respectively. Using the Kaplan−Meier method, the Eastern Cooperative Oncology Group performance status 0, serum albumin levels ≥4.2 g/dL, hemoglobin levels ≥13.2 g/dL, C-reactive protein levels <0.21 mg/dL, clinical T stage ≤2, clinically negative lymph node (LN) status, and tumor size <30 mm were associated with a significantly better CSS. In the multivariate analysis, the clinically positive LN status was a significant predictive factor for CSS in patients with PSCC. Further prospective large-scale and long-term studies are required to validate our findings.

Indexed as

Carcinoma, Squamous CellPenile NeoplasmsEpithelial CellsHumansLymphatic MetastasisLymph NodesMalePrognosisRetrospective Studiescancer-specific survivalinflammatory markerslymph node involvementpenile cancer

Identifiers

PMID36005170
PMCPMC9406784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.