Evidence map›Paper›PMID 36005048›Full record

ReviewBiosensors2022

Electrochemical Biosensors for Circulating Tumor DNA Detection.

Ke Wang, Zhijia Peng, Xiaogang Lin, Weiqi Nian, Xiaodong Zheng, Jayne Wu

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ke WangKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China.ORCID 0000-0003-2830-8480
Zhijia PengKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China.
Xiaogang LinKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China.
Weiqi NianChongqing University Cancer Hospital, Chongqing University, Chongqing 400044, China.
Xiaodong ZhengChongqing University Cancer Hospital, Chongqing University, Chongqing 400044, China.
Jayne WuDepartment of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0001-5143-9425

Funding

Graduate Research and Innovation Foundation of Chongqing, China CYS22108the Fundamental Research Funds for the Central Universities 2019CDYGZD006the Postgraduate Education and Teaching Reform Research Project of Chongqing University cquyjg18323Venture & Innovation Support Program for Chongqing Overseas Returnees and Fundamental Research Funds for the Central Universities 10611CDJXZ238826
6 · The paper itself

Abstract

Early diagnosis and treatment have always been highly desired in the fight against cancer, and detection of circulating tumor DNA (ctDNA) has recently been touted as highly promising for early cancer-screening. Consequently, the detection of ctDNA in liquid biopsy is gaining much attention in the field of tumor diagnosis and treatment, which has also attracted research interest from industry. However, it is difficult to achieve low-cost, real-time, and portable measurement of ctDNA in traditional gene-detection technology. Electrochemical biosensors have become a highly promising solution to ctDNA detection due to their unique advantages such as high sensitivity, high specificity, low cost, and good portability. Therefore, this review aims to discuss the latest developments in biosensors for minimally invasive, rapid, and real-time ctDNA detection. Various ctDNA sensors are reviewed with respect to their choices of receptor probes, designs of electrodes, detection strategies, preparation of samples, and figures of merit, sorted by type of electrode surface recognition elements. The development of biosensors for the Internet of Things, point-of-care testing, big data, and big health is analyzed, with a focus on their portable, real-time, and non-destructive characteristics.

Indexed as

Biosensing TechniquesCirculating Tumor DNANeoplasmsBiomarkers, TumorEarly Detection of CancerElectrochemical TechniquesHumansLiquid BiopsyBiomarkers, TumorCirculating Tumor DNAbiosensorscirculating tumor DNA (ctDNA)high sensitivityInternet of Thingsnon-destructivereal-time detection

Identifiers

PMID36005048
PMCPMC9406149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.