Evidence map›Paper›PMID 36005035›Full record

ReviewBiosensors2022

Liquid Crystal Biosensors: Principles, Structure and Applications.

Haonan Wang, Tianhua Xu, Yaoxin Fu, Ziyihui Wang, Mark S Leeson, Junfeng Jiang, Tiegen Liu

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Spontaneous phase separation and pattern formation in a lyotropic nematic mixture.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Liquid crystalline system for drug delivery: structural insights, preparation techniques and translational potential.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haonan WangSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.ORCID 0000-0001-8388-4494
Tianhua XuSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.ORCID 0000-0002-5510-841X
Yaoxin FuSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
Ziyihui WangSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.
Mark S LeesonSchool of Engineering, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0003-0367-6228
Junfeng JiangSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.ORCID 0000-0003-0393-8451
Tiegen LiuSchool of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.

Funding

China Scholarship Council 202006250152EU Horizon 2020 MSCA 101008280National Natural Science Foundation of China 61735011
6 · The paper itself

Abstract

Liquid crystals (LCs) have been widely used as sensitive elements to construct LC biosensors based on the principle that specific bonding events between biomolecules can affect the orientation of LC molecules. On the basis of the sensing interface of LC molecules, LC biosensors can be classified into three types: LC-solid interface sensing platforms, LC-aqueous interface sensing platforms, and LC-droplet interface sensing platforms. In addition, as a signal amplification method, the combination of LCs and whispering gallery mode (WGM) optical microcavities can provide higher detection sensitivity due to the extremely high quality factor and the small mode volume of the WGM optical microcavity, which enhances the interaction between the light field and biotargets. In this review, we present an overview of the basic principles, the structure, and the applications of LC biosensors. We discuss the important properties of LC and the principle of LC biosensors. The different geometries of LCs in the biosensing systems as well as their applications in the biological detection are then described. The fabrication and the application of the LC-based WGM microcavity optofluidic sensor in the biological detection are also introduced. Finally, challenges and potential research opportunities in the development of LC-based biosensors are discussed.

Indexed as

Biosensing TechniquesLiquid CrystalsLC-based biosensorsliquid crystalsmicrofluidicsoptofluidicwhispering gallery mode

Identifiers

PMID36005035
PMCPMC9406233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.