Evidence map›Paper›PMID 36004813›Full record

ArticleNeurorehabilitation and neural repair2022

Increasing the Amount and Intensity of Stepping Training During Inpatient Stroke Rehabilitation Improves Locomotor and Non-Locomotor Outcomes.

Christopher E Henderson, Abbey Plawecki, Emily Lucas, Jennifer K Lotter, Molly Scofield, Angela Carbone, Jeong H Jang, T George Hornby

Open access · greenAbstract read
In one paragraph

Article in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  11. High-Intensity Gait Training for Patients After Stroke: A Feasibility Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christopher E HendersonDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-9464-2789
Abbey PlaweckiRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Emily LucasRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Jennifer K LotterRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Molly ScofieldRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Angela CarboneDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.
Jeong H JangDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
T George HornbyDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-3147-3818
Rehabilitation Hospital of Indiana · USIndiana University School of Medicine

Funding

Locomotor Recovery and Compensation Post-strokeR01NS118009 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Thomas George Hornby · 2021 to 2026
$2.0M
Variable Intensive Early Walking post-Stroke (VIEWS)R01HD108622 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI Thomas George Hornby · 2023 to 2026
$1.9M
Sympathetic-somatomotor coupling in human SCIR01NS079751 · NINDS · MARQUETTE UNIVERSITY · PI HORNBY, THOMAS GEORGE, SCHMIT, BRIAN D · 2013 to 2017
$1.6M
NICHD NIH HHS R01 HD108622NINDS NIH HHS R01 NS079751NINDS NIH HHS R01 NS118009
6 · The paper itself

Abstract

backgroundThe efficacy of traditional rehabilitation interventions to improve locomotion post-stroke, including providing multiple exercises targeting impairments and activity limitations, is uncertain. Emerging evidence rather suggests attempts to prioritize stepping practice at higher cardiovascular intensities may facilitate greater locomotor outcomes.

objectiveThe present study was designed to evaluate the comparative effectiveness of high-intensity training (HIT) to usual care during inpatient rehabilitation post-stroke.

methodsChanges in stepping activity and functional outcomes were compared over 9 months during usual-care (n = 131 patients < 2 months post-stroke), during an 18-month transition phase with attempts to implement HIT (n = 317), and over 12 months following HIT implementation (n = 208). The transition phase began with didactic and hands-on education, and continued with meetings, mentoring, and audit and feedback. Fidelity metrics included percentage of sessions prioritizing gait interventions and documenting intensity. Demographics, training measures, and outcomes were compared across phases using linear or logistic regression analysis, Kruskal-Wallis tests, or χ

resultsAcross all phases, admission scores were similar except for balance (usual-care>HIT;

conclusionsGreater efforts to prioritize walking and reach higher intensities during HIT led to increased steps/day, resulting in greater gains in locomotor and non-locomotor outcomes.

Indexed as

StrokeStroke RehabilitationExercise TherapyGaitHumansInpatientsWalkingexerciselocomotionrehabilitation

Identifiers

PMID36004813
PMCPMC10189784
OpenAlexW4293090815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.