Evidence map›Paper›PMID 36004747›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.

Mitchell L Onslow, Jennifer Wolsk, Stephen Wisniewski, Sanjay Patel, Marcia Gallaher, Carl Hubel, David J Cashmere, Francesca L Facco

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02086448 (Sleep Disordered Breathing, Obesity and Pregnancy Study), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02086448 nacompletednot on this map

Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)

TypeinterventionalSponsorFrancesca Facco, MDRan2014 to 2022Enrolled242ConditionsObese, Pregnancy, Sleep Disordered BreathingArmsCPAP, sham-CPAP, Sleep hygiene
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mitchell L OnslowDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jennifer WolskGraduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Stephen WisniewskiGraduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Sanjay PatelCenter for Sleep and Cardiovascular Outcomes Research, Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Marcia GallaherMagee-Womens Research Institute, Pittsburgh, Pennsylvania.
Carl HubelDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
David J CashmereUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Francesca L FaccoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
University of Pittsburgh · USMagee-Womens Research Institute · USUniversity of Pittsburgh Medical Center · US

Funding

Sleep Disordered Breathing, Obesity, and Pregnancy StudyR01HL120354 · NHLBI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI FACCO, FRANCESCA L · 2014 to 2018
$3.3M
NHLBI NIH HHS R01 HL120354
6 · The paper itself

Abstract

STUDY

objectivesTo evaluate the impact of sleep-disordered breathing (SDB) on vascular, angiogenic and metabolic analytes in pregnancy.

methodsParticipants with a body mass index ≥30 kg/m

resultsA total of 242 and 130 participants completed visit 1 and visit 2, respectively. Newly diagnosed SDB was present in 37% of individuals at visit 1 and 31% of individuals at visit 2. No significant differences in our composite outcome vector were observed in individuals with and without SDB at either visit. In our secondary analysis, mean arterial blood pressure (88.7 ± 7.3 mm Hg vs 85.4 ± 7.1 mm Hg,

conclusionsSDB in early pregnancy was not associated with our composite primary outcome but was associated with higher mean arterial blood pressure and fasting glucose. The pathophysiologic changes that occur in pregnant individuals with SDB and how they lead to an increased risk of preeclampsia and gestational diabetes remain poorly understood. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP); URL: https://clinicaltrials.gov/ct2/show/NCT02086448; Identifier: NCT02086448. CITATION: Onslow ML, Wolsk J, Wisniewski S, et al. The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.

Indexed as

Insulin ResistanceSleep Apnea SyndromesAnimalsArterial PressureCatsFemaleHumansObesityPlacenta Growth FactorPregnancyPlacenta Growth Factorendothelialmetabolicpregnancysleep-disordered breathing

Identifiers

PMID36004747
PMCPMC9806794
OpenAlexW4293105309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.