ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2022
Relationship between Depression and Constipation: Results from a Large Cross-sectional Study in Adults.
Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Constipation is associated with an increased risk of depression: A systematic review and meta-analysis of observational studies.Translational psychiatry · 2026Pooled it
- Research on functional constipation with anxiety or depression: a bibliometric analysis.Frontiers in psychiatry · 2025Pooled it
- Gastrointestinal Issues in Depression, Anxiety, and Neurodegenerative Diseases: A Systematic Review on Pathways and Clinical Targets Implications.CNS & neurological disorders drug targets · 2024Pooled it
- Daily consumption of galactooligosaccharide gummies ameliorates constipation symptoms, gut dysbiosis, degree of depression and quality of life among sedentary university teaching staff: A double-blind randomized placebo control clinical trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Trial
- Evaluation of the Intervention Effect ofNutrients · 2026Article
- Relationship Between Depression and Constipation: A Cross-Sectional Health Report From the PERSIAN Guilan Cohort Study (PGCS).Health science reports · 2026Article
- Twenty-Five Years of Pathophysiology-Based Surgery of Slow-Transit Constipation: Outcomes After Segmental, Subtotal and Total Colectomy.Journal of clinical medicine · 2026Article
- Prevalence, severity, and risk factors for depressive and anxiety symptoms among adolescents: A cross-sectional study.World journal of psychiatry · 2026Article
- Elucidating the Mechanism of the Liqi Yangyin Formula in Treating Depression-Constipation Comorbidity: An Integrative Approach Using Network Pharmacology and Experimental Validation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The microbiota-gut-brain axis perspective: mechanisms and intervention strategies for the comorbidity of chronic constipation and depression.Frontiers in microbiology · 2026Review
- Bidirectional associations of depression, anxiety, sleep disorders, and constipation: insights from Mendelian randomization.Archives of medical science : AMS · 2026Article
- Postmarketing surveillance of elobixibat for patients with chronic constipation and concomitant schizophrenia or depression in Japan.Frontiers in psychiatry · 2026Article
- Impact of Dysmenorrhea Severity on Mental Wellbeing and Quality of Life Among Saudi Women: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Pathophysiological mechanisms, diagnostic innovations, and multimodal therapeutic strategies for slow transit constipation.BMC gastroenterology · 2025Review
- Depressive Symptoms, Dietary Patterns and Other Factors Associated with Constipation in Middle-Aged Adults from Kielce District in Poland: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Electroconvulsive therapy improves distal colonic motility via the subdiaphragmatic vagus nerve in depressive-like mice.Scientific reports · 2025Article
- Association of constipation with suicidal ideation among US adults and the partial mediating role of depression.Scientific reports · 2025Article
- Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut Microecology.Drug design, development and therapy · 2025Article
- Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis.Psychology research and behavior management · 2025Article
- Dietary inflammation and socioeconomic status mediate depression-constipation link: a cross-sectional analysis of NHANES 2005-2010.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Accumulating evidence based on a few studies suggests a relationship between depression and functional constipation. This study examined whether depression is associated with a higher risk of functional constipation and whether it is gender specific. Methods: This cross-sectional study was carried out on 3,362 adults aged 18-55 years. In this study, functional gastrointestinal symptoms were determined using an Iranian reliable and valid version of the modified Rome III questionnaire. The Iranian validated version of the hospital anxiety and depression scale was used to evaluate the psychological health. Scores of eight or more on the depression subscale in the questionnaire were considered the presence of depression. Simple and multiple binary logistic regression were used for data analysis. Results: The mean±SD age of participants was 36.29±7.87 years, and 58.5% were female. The prevalence of depression and constipation in the study sample was 28.6% and 23.9%, respectively. In the full adjusted model, in the total sample, depressed people showed a significantly higher risk of constipation; adjusted OR (AOR), 1.69 (95% CI, 1.37-2.09). Although a significant association was observed between depression and constipation in both genders, the association was stronger in men than women (AOR, 2.28; 95% CI, 1.50, 3.63 vs. AOR, 1.55; 95% CI, 1.21, 1.99). Conclusions: These study findings showed that depressed people are at a significantly higher risk of being affected by constipation. The current study findings justify the importance of mental health evaluations in all patients with functional gastrointestinal disorders, particularly among constipated individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.