ArticlePsychological medicine2023
Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Nucleus Reuniens-Elicited Delta Oscillations Disable the Prefrontal Cortex in Schizophrenia.Cells · 2025Review
- Morphological alterations of the thymus gland in individuals with schizophrenia.Molecular psychiatry · 2025Article
- Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events.Molecular psychiatry · 2025Article
- Molecular and micro-architectural mapping of gray matter alterations in psychosis.Molecular psychiatry · 2025Article
- A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.Noro psikiyatri arsivi · 2025Review
- Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia.Psychoradiology · 2025Article
- Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow.Schizophrenia (Heidelberg, Germany) · 2024Article
- Case series of patients with early psychosis presenting hypoperfusion in angular gyrus and self-disturbance: Implication for the sense of agency and schizophrenia.Neuropsychopharmacology reports · 2024Article
- Animal Model Reveals Mechanism of Hippocampal Hyperactivity in Psychosis.Schizophrenia bulletin · 2023Article
- Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAltered cerebral blood flow (CBF) has been found in people at risk for psychosis, with first-episode psychosis (FEP) and with chronic schizophrenia (SCZ). Studies using arterial spin labelling (ASL) have shown reduction of cortical CBF and increased subcortical CBF in SCZ. Previous studies have investigated CBF using ASL in FEP, reporting increased CBF in striatum and reduced CBF in frontal cortex. However, as these people were taking antipsychotics, it is unclear whether these changes are related to the disorder or antipsychotic treatment and how they relate to treatment response.
methodsWe examined CBF in FEP free from antipsychotic medication (
resultsThere was significantly lower absolute CBF in frontal cortex (Cohen's
conclusionsThese results show lower cortical absolute perfusion in FEP prior to starting antipsychotic treatment and suggest relative-to-global frontal CBF as assessed with magnetic resonance imaging could potentially serve as a biomarker for antipsychotic response.
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Registered trials
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