Evidence map›Paper›PMID 36004383›Full record

ArticleApplied sciences (Basel, Switzerland)2021

Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration.

Kwan-Hee Yun, Mi-Ja Ko, Yong-Kown Chae, Koeun Lee, Ok-Hyung Nam, Hyo-Seol Lee, Kyounga Cheon, Sung-Chul Choi

Open access · goldAbstract read
In one paragraph

Article in Applied sciences (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kwan-Hee YunDepartment of Pediatric Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Mi-Ja KoDepartment of Pediatric Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Yong-Kown ChaeDepartment of Pediatric Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Koeun LeeDepartment of Pediatric Dentistry, Kyung Hee University Dental Hospital, Seoul 17104, Korea.
Ok-Hyung NamDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-6386-803X
Hyo-Seol LeeDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-7287-5082
Kyounga CheonDepartment of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-0629-097X
Sung-Chul ChoiDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-7221-2000
Kyung Hee University · KRKyung Hee University Dental Hospital · KRUniversity of Alabama at Birmingham · US

Funding

NITRIC OXIDE RELEASING BIOMIMETRIC NANOMATRIX GELF OR ROOT REVITALIZATIONK08DE027401 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEON, KYOUNGA · 2017 to 2022
$798k
NIDCR NIH HHS K08 DE027401
6 · The paper itself

Abstract

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treatment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard deviation) compared to the no treatment group (2.21 ± 1.25,

Indexed as

avulsionnanomatrix gelnitric oxidepulp regenerationreplantation

Identifiers

PMID36004383
PMCPMC9397492
OpenAlexW3176977696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.