Evidence map›Paper›PMID 36004322›Full record

ArticleFrontiers in rehabilitation sciences2021

Transcutaneous Electrical Spinal Cord Stimulation to Promote Recovery in Chronic Spinal Cord Injury.

Candace Tefertiller, Meghan Rozwod, Eric VandeGriend, Patricia Bartelt, Mitch Sevigny, Andrew C Smith

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in rehabilitation sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07361627 (Improving Upper Limb Motor Control With Spinal Stimulation), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07361627 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Improving Upper Limb Motor Control With Spinal Stimulation

TypeinterventionalSponsorCentre for Interdisciplinary Research in Rehabilitation of Greater MontrealRan2026 to 2028Enrolled40ConditionsSpinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)ArmsProtocol 1: Combination of activity-based therapy and sham spinal cord stimulation, Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Candace TefertillerCraig Hospital, Englewood, CO, United States.
Meghan RozwodCraig Hospital, Englewood, CO, United States.
Eric VandeGriendCraig Hospital, Englewood, CO, United States.
Patricia BarteltCraig Hospital, Englewood, CO, United States.
Mitch SevignyCraig Hospital, Englewood, CO, United States.
Andrew C SmithDepartment of Physical Medicine and Rehabilitation, University of Colorado, Denver, CO, United States.
Craig Hospital · USUniversity of Colorado Denver · US

Funding

MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
NICHD NIH HHS K12 HD055931
6 · The paper itself

Abstract

Objective: To evaluate the impact of using transcutaneous electrical spinal cord stimulation (TSCS) on upper and lower extremity function in individuals with chronic spinal cord injury (SCI). Design: Prospective case series. Setting: SCI specific rehabilitation hospital. Participants: A convenience sample ( Interventions: Individuals participated in 60 min of upper extremity (UE) functional task-specific practice (FTP) in combination with TSCS and 60 min of locomotor training in combination with TSCS 5x/week. Main Outcome Measures: The primary outcome for this analysis was the Capabilities of Upper Extremity Test (CUE-T). Secondary outcomes include UE motor score (UEMS), LE motor score (LEMS), sensation (light touch and pin prick), Nine-Hole Peg Test, 10 meter walk test, 6 min walk test, and 5 min stand test. Results: Seven individuals (four motor complete; three motor incomplete) completed 20-80 sessions UE and LE training augmented with TSCS and without any serious adverse events. Improvements were reported on the CUE-T in all seven individuals. Two individuals improved their ASIA impairment scale (AIS) classification (B to C; C to D) and two individuals improved their neurologic level of injury by one level (C4-C5; C5-C6). Sensation improved in five individuals and all four who started out with motor complete SCIs were able to voluntarily activate their LEs on command in the presence of stimulation. Conclusion: Individuals with chronic SCI who had previously demonstrated a plateau in function after an intensive outpatient therapy program were able to improve in a variety of UE and LE outcomes in response to TSCS without any adverse events. This was a small pilot study and future fully powered studies with comparative interventions need to be completed to assess efficacy.

Indexed as

neuromodulationspinal cord injurytask-specifictetraplegiatranscutaneous electrical spinal cord stimulation

Identifiers

PMID36004322
PMCPMC9396932
OpenAlexW4205321249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.