Evidence map›Paper›PMID 36004302›Full record

ArticleJTCVS open2020

Impact of tricuspid valve insufficiency on the performance of left ventricular assist devices.

Claudio J R Gomez Hamacher, Carolin Torregroza, Najla Sadat, Daniel Scheiber, Jil-Cathrin von der Beek, Ralf Westenfeld, Ivonne Jeanette Knorr, Martin Sager, Artur Lichtenberg, Diyar Saeed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Tricuspid surgery at the time of LVAD implant: A critique.Frontiers in cardiovascular medicine · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Claudio J R Gomez HamacherDepartment of Cardiovascular Surgery, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Carolin TorregrozaDepartment of Anesthesiology, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Najla SadatDepartment of Cardiovascular Surgery, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Daniel ScheiberDivision of Cardiology, Pneumology and Angiology, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Jil-Cathrin von der BeekCentral Unit for Animal Research and Animal Welfare Affairs, Heinrich-Heine University, Dusseldorf, Germany.
Ralf WestenfeldDivision of Cardiology, Pneumology and Angiology, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Ivonne Jeanette KnorrCentral Unit for Animal Research and Animal Welfare Affairs, Heinrich-Heine University, Dusseldorf, Germany.
Martin SagerCentral Unit for Animal Research and Animal Welfare Affairs, Heinrich-Heine University, Dusseldorf, Germany.
Artur LichtenbergDepartment of Cardiovascular Surgery, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Diyar SaeedDepartment of Cardiovascular Surgery, University Hospital, Heinrich-Heine University, Dusseldorf, Germany.
Düsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the impact of severe tricuspid valve insufficiency (TVI) at the time of left ventricular assist device (LVAD) implantation on the hemodynamic and LVAD parameters in an acute ovine model. Methods: Stable heart failure (HF) was induced in 10 ovines through the application of 3 ± 1 coronary ligations. Once stable HF was obtained (after 15 ± 5 days), the animals were supported with an LVAD. Hemodynamic data and pump parameters were obtained and compared in 2 settings; first with LVAD in place after weaning from the cardiopulmonary bypass machine (no TVI condition) and second following the induction of severe TVI through resection of the tricuspid valve (TVI condition). Results: There were no statistically significant differences in the hemodynamic and pump parameters between TVI condition and no TVI conditions except for lower cardiac output in the TVI condition (2 [1.38-2.8] L/min vs 3.2 [1.55-3.7] L/min, Conclusions: Results from this acute animal study suggest that severe TVI in HF with preserved right ventricular function does not have significant impact on the LVAD pump parameters. The observed reduction in cardiac output may warrant further investigations, especially under loading conditions.

Indexed as

animal modelbpm, beats per minuteCO, cardiac outputcoronary ligationCPB, cardiopulmonary bypassCVP, central venous pressureheart failureHF, heart failureHR, heart rateLVAD, left ventricular assist deviceMAP, mean arterial pressuremPAP, mean pulmonary artery pressureovine modelPAPi, pulmonary artery pulsatility indexRVF, right ventricle failureRV, right ventriculartricuspid regurgitationtricuspid valve insufficiencyTVI, tricuspid valve insufficiencyTVR, tricuspid valve reconstructionventricular assist device

Identifiers

PMID36004302
PMCPMC9390470
OpenAlexW3088788895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.