Evidence map›Paper›PMID 36004249›Full record

ArticleJTCVS open2022

Cardio-omentopexy requires a cardioprotective innate immune response to promote myocardial angiogenesis in mice.

Zhi-Dong Ge, Riley M Boyd, Connor Lantz, Edward B Thorp, Joseph M Forbess

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhi-Dong GeThe Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Riley M BoydThe Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Connor LantzThe Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Edward B ThorpThe Heart Center and Cardiovascular-Thoracic Surgery, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Joseph M ForbessDepartment of Surgery, University of Maryland School of Medicine and The Children's Heart Program, University of Maryland Children's Hospital, Baltimore, Md.
Lurie Children's Hospital · USUniversity of Maryland, Baltimore · US

Funding

Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
NHLBI NIH HHS R01 HL122309
6 · The paper itself

Abstract

Objective: The pedicled greater omentum, when applied onto stressed hearts using omentopexy, has been shown to be protective in humans and animals. The mechanisms underlying cardioprotection using omentopexy remain elusive. This study examined whether macrophage-mediated angiogenesis accounts for the cardioprotective effect of omentopexy in mice. Methods: C57BL/6 mice were subjected to minimally invasive transverse aortic constriction for 6 weeks and subsequent cardio-omentopexy for 8 weeks. Control mice underwent the same surgical procedures without aortic constriction or cardio-omentopexy. Results: Transverse aortic constriction led to left ventricular concentric hypertrophy, reduced mitral E/A ratio, increased cardiomyocyte size, and myocardial fibrosis in the mice that underwent sham cardio-omentopexy surgery. The negative effects of transverse aortic constriction were prevented by cardio-omentopexy. Myocardial microvessel density was elevated in the mice that underwent aortic constriction and sham cardio-omentopexy surgery, and cardio-omentopexy further enhanced angiogenesis. Nanostring gene array analysis uncovered the activation of angiogenesis gene networks by cardio-omentopexy. Flow cytometric analysis revealed that cardio-omentopexy triggered the accumulation of cardiac MHCII Conclusions: Cardio-omentopexy protects the heart from pressure overload-elicited left ventricular hypertrophy and dysfunction by promoting myocardial angiogenesis. Cardiac MHCII Video Abstract:

Indexed as

Akt, protein kinase BangiogenesisAXL, AXL receptor tyrosine kinaseCalm1, calmodulin 1cardiac hypertrophycardio-omentopexyCD45, lymphocyte common antigenCD64, cluster of differentiation 64Cdh5, cadherin 5Clodro, clodronate-liposomesCOP, cardio-omentopexyCrk, proto-oncogene c-CrkCtnnb1, catenin β1Ctnnd1, catenin delta 1Cybb, cytochrome B-245 beta chainCyfip1, cytoplasmic FMR1 interacting protein 1ECM, extracellular matrixF4/80, F4/80 antigenHCM, hypertrophic cardiomyopathyHippo, hippocampalHSP89aa1, heat shock protein 89aa1iB4, biotinylated-isolectin B4Itpr2, inositol 1,4,5-trisphosphate receptor type 2Kdr, kinase insert domain receptorKras, kirsten rat sarcoma virusLV, left ventricleLy6Clo, lymphocyte antigen-6ClowLy6G, lymphocyte antigen 6 complex locus G6DLyve1, lymphatic vessel endothelial hyaluronan receptor 1macrophagesMHCIIlo, major histocompatibility complex class IIlowmTOR, mammalian target of rapamycinNcf1, neutrophil cytosolic factor 1Nck2, NCK adaptor protein 2Nckap1H, NCK-associated protein 1HNos3, nitric oxide synthase 3PBS, phosphate-buffered salinePDGF, platelet-derived growth factorPI3K, phosphoinositide-3-kinasePlcg1, phospholipase Cγ1Plcg2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase γ2Prkaca, protein kinase cAMP-activated catalytic subunit αPrkacb, protein kinase cAMP-activated catalytic subunit βPrkca, protein kinase CαPtk2b, protein tyrosine kinase 2βPtk2, protein tyrosine kinase 2Rac1, Rac family small GTPase 1Rock2, Rho associated coiled-coil containing protein kinase 2Src, proto-oncogene tyrosine-protein kinase SrcTAC, transverse aortic constrictionTGF, transforming growth factorTimD4, T cell immunoglobulin and mucin domain conataining 4Vav1, Vav guanine nucleotide exchange factor 1VEGF-A, vascular endothelial growth factor AWGA, wheat germ agglutinin

Identifiers

PMID36004249
PMCPMC9390370
OpenAlexW4214548666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.