Evidence map›Paper›PMID 36004079›Full record

ArticleJTCVS open2021

Aortic valve endocarditis in patients with bicuspid and tricuspid aortic valves.

Tan Le, Nathan J Graham, Aroma Naeem, Jeffrey Clemence, Juan Caceres, Xiaoting Wu, Himanshu J Patel, Karen M Kim, G Michael Deeb, Bo Yang

Abstract read
In one paragraph

Article in JTCVS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tan LeDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Nathan J GrahamUniversity of Michigan Medical School, Ann Arbor, Mich.
Aroma NaeemDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Jeffrey ClemenceDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Juan CaceresUniversity of Michigan Medical School, Ann Arbor, Mich.
Xiaoting WuDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Himanshu J PatelDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Karen M KimDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
G Michael DeebDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Bo YangDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.

Funding

Therapeutic Insights into Loeys-Dietz Syndrome using Humanized ModelsR01HL151776 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bo Yang · 2020 to 2026
$4.2M
Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
Effect of mutations in the TGF-beta pathway genes on smooth muscle cell differentiation using patient derived iPSCs.K08HL130614 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2016 to 2020
$848k
NHLBI NIH HHS K08 HL130614NHLBI NIH HHS R01 HL141891NHLBI NIH HHS R01 HL151776
6 · The paper itself

Abstract

Objective: To determine the long-term survival and rate of reoperation after surgical treatment of infective endocarditis (IE) in patients with a bicuspid aortic valve (BAV) and patients with a tricuspid aortic valve (TAV). Methods: Between 1997 and 2017, 210 patients underwent surgical treatment for native aortic valve endocarditis, including 51 patients with BAV (24%) and 159 patients with TAV (76%). Data were obtained from the Society of Thoracic Surgeons data warehouse and hospital medical record review, supplemented with surveys and national death index data for more complete follow-up. Results: Compared with the TAV IE group, the BAV IE group was significantly younger (42 years vs 54 years) and had lower incidence rates of hypertension, coronary artery disease, and congestive heart failure (CHF). There were no significant between-group differences in postoperative stroke, sepsis, pacemaker requirement, or in-hospital mortality (2.0% vs 4.4%). Liver disease was a risk factor for operative mortality (odds ratio [OR], 13; 95% CI, 3.3-30; Conclusions: BAV patients develop IE requiring surgery at a younger age than TAV patients, but have significantly better long-term survival. Early detection of BAV is important to prevent IE and provide aggressive surgical treatment should IE occur.

Indexed as

AI, aortic insufficiencyaortic valveaortic valve replacementAVR, aortic valve replacementBAV, bicuspid aortic valvebicuspid aortic valveendocarditisHR, hazard ratioIE, infective endocarditisIQR, interquartile rangeIV, intravenousOR, odds ratioreoperationsurvivalTAV, tricuspid aortic valve

Identifiers

PMID36004079
PMCPMC9390515

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.