ArticleFrontiers in psychiatry2022
High-intensity interval training may reduce depressive symptoms in individuals with schizophrenia, putatively through improved VO
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Aerobic High Intensity Training on Symptoms, Cognition, Cortical Structure, Substance Use and Metabolic Indices in Patients With Schizophrenia Spectrum Disorder
Moderate-to-Vigorous Intensity Physical Activity as a Tool for Severe Mental Illness Recuperation Process: Study Protocol for a Pragmatic Controlled Clinical Trial (+moviMENT)
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Impact of Structured Physical Exercise Programs (SPEs) on Symptoms and Clinical Outcomes in Schizophrenia: A Systematic Review With Qualitative Synthesis of Randomized Controlled Trials (2015-2025).Actas espanolas de psiquiatria · 2026Pooled it
- Neurotrophin System as a Complex Set of Potential Biomarkers in Psychiatric Disorders and Therapy-Overview of Recent Advances.International journal of molecular sciences · 2026Review
- The effectiveness of high-intensity interval training (HIIT) in adults with psychiatric disorders: a scoping review.Social psychiatry and psychiatric epidemiology · 2026Review
- Affective Reactivity to a Single Bout of High-Intensity Interval Training in Schizophrenia: A Randomized Controlled Trial.Schizophrenia bulletin open · 2026Article
- Article
- Influence of upper-body high-intensity intermittent training on energy metabolism and maximal oxygen uptake in elite swimmers.Frontiers in physiology · 2025Article
- Neuroinflammation and schizophrenia - is there a link?Frontiers in psychiatry · 2024Article
- Muscle Quality Index is inversely associated with psychosocial variables among Chilean adolescents.BMC public health · 2023Article
- "Out-of-Hospital and with Qualified Exercise Professionals": Keys to the CORTEX-SP Physical Exercise Program According to the Experience of the Participants.European journal of investigation in health, psychology and education · 2023Article
- Effects of 8 months of high-intensity interval training on physical fitness and health-related quality of life in substance use disorder.Frontiers in psychiatry · 2023Article
- Alterations in inflammatory markers after a 12-week exercise program in individuals with schizophrenia-a randomized controlled trial.Frontiers in psychiatry · 2023Article
- Clinical value and mechanistic analysis of HIIT on modulating risk and symptoms of depression: A systematic review.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: High-intensity interval training (HIIT) may improve cardiorespiratory fitness (CRF) and mental health. The current observer-blinded RCT investigates the sparsely studied efficiency of HIIT in reducing psychotic and non-psychotic symptoms in schizophrenia and complements previous studies by investigating whether symptom reduction following HIIT is associated with, putatively partly mediated by, increased VO Methods: Participants (outpatients meeting diagnostic criteria for schizophrenia) were randomized to HIIT ( Results: Depressive symptoms (baseline score 3.97, 95% Conclusion: HIIT reduced depressive symptoms more than AVG, which persisted at follow-up. HIIT may serve as a complementing treatment option targeting these symptoms in individuals with schizophrenia, even before they reach clinical depression. Depressive symptoms are important to prevent, stabilize, and treat due to their negative implications for psychological wellbeing and long-term functional outcome. Reduction in depressive symptoms was associated with improved VO Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [NCT02205684].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.