Evidence map›Paper›PMID 36003960›Full record

ArticleFrontiers in neuroscience2022

Selective blockade of rat brain T-type calcium channels provides insights on neurophysiological basis of arousal dependent resting state functional magnetic resonance imaging signals.

Vahid Khalilzad Sharghi, Eric A Maltbie, Wen-Ju Pan, Shella D Keilholz, Kaundinya S Gopinath

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vahid Khalilzad SharghiDepartment of Biomedical Engineering, Emory University-Georgia Tech, Atlanta, GA, United States.
Eric A MaltbieDepartment of Biomedical Engineering, Emory University-Georgia Tech, Atlanta, GA, United States.
Wen-Ju PanDepartment of Biomedical Engineering, Emory University-Georgia Tech, Atlanta, GA, United States.
Shella D KeilholzDepartment of Biomedical Engineering, Emory University-Georgia Tech, Atlanta, GA, United States.
Kaundinya S GopinathDepartment of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States.
Georgia Institute of Technology · USEmory University · US

Funding

Examining the Effects of Suppression of Slow Rhythms on Resting State fMRIR21NS122013 · NINDS · EMORY UNIVERSITY · PI GOPINATH, KAUNDINYA SRINIVASAN, KEILHOLZ, SHELLA D · 2021 to 2021
$430k
NINDS NIH HHS R21 NS122013
6 · The paper itself

Abstract

A number of studies point to slow (0.1-2 Hz) brain rhythms as the basis for the resting-state functional magnetic resonance imaging (rsfMRI) signal. Slow waves exist in the absence of stimulation, propagate across the cortex, and are strongly modulated by vigilance similar to large portions of the rsfMRI signal. However, it is not clear if slow rhythms serve as the basis of all neural activity reflected in rsfMRI signals, or just the vigilance-dependent components. The rsfMRI data exhibit quasi-periodic patterns (QPPs) that appear to increase in strength with decreasing vigilance and propagate across the brain similar to slow rhythms. These QPPs can complicate the estimation of functional connectivity (FC)

Indexed as

animal studiesarousalcortical slow wave activityquasiperiodic patternsresting state fMRIT-type calcium channel blockervigilance

Identifiers

PMID36003960
PMCPMC9393715
OpenAlexW4290615635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.