ArticleClinical kidney journal2022
Triglycerides-glucose index and the risk of cardiovascular events in persons with non-diabetic chronic kidney disease.
Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.Cardiovascular diabetology · 2025Pooled it
- Triglyceride-glucose index and the outcome of peritoneal dialysis patients: analysis of two cohorts.BMC nephrology · 2026Article
- Insulin Resistance and Atherogenic Dyslipidemia Drive Cardiac Remodeling and Cardiovascular Events After Kidney Transplantation.Journal of clinical medicine · 2026Article
- The triglyceride-glucose index in chronic kidney disease: a narrative review.Frontiers in nutrition · 2026Review
- Cardiovascular risk prediction in hemodialysis patients using the triglyceride-glucose index: a multicenter prospective cohort study.Clinical kidney journal · 2025Article
- Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project.Cardiovascular diabetology · 2025Article
- Change in adiposity indices after 1 year of peritoneal dialysis: a single-center cohort study.Clinical kidney journal · 2025Article
- Association of the Triglyceride-Glucose Index with Body Composition and Laboratory Parameters in Chronic Kidney Disease Stages 3-5.Risk management and healthcare policy · 2025Article
- Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study.BMC cardiovascular disorders · 2024Article
- Triglyceride glucose index: a significant prognostic marker of heart failure in patients with chronic kidney disease.Renal failure · 2024Article
- Associations of baseline and changes in the triglyceride glucose-weight adjusted waist index and cardiovascular disease risk: evidence from middle-aged and older individuals.Cardiovascular diabetology · 2024Article
- Evaluating the impact of chronic kidney disease and the triglyceride-glucose index on cardiovascular disease: mediation analysis in the NHANES.BMC public health · 2024Article
- Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease.International urology and nephrology · 2024Article
- Impact of diabetes mellitus and triglyceride glucose index on mortality and cardiovascular outcomes in patients with chronic coronary syndrome undergoing coronary computed tomography angiography.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients.Kidney international reports · 2023Article
- Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients.Renal failure · 2023Article
- Non-insulin-based insulin resistance indices for predicting all-cause mortality and renal outcomes in patients with stage 1-4 chronic kidney disease: another paradox.Frontiers in nutrition · 2023Article
- High triglyceride-glucose index is associated with poor cardiovascular outcomes in Chinese acute coronary syndrome patients without diabetes mellitus who underwent emergency percutaneous coronary intervention with drug-eluting stents.Frontiers in endocrinology · 2023Article
- A promising tool: triglyceride-glucose index to stratify the risk of cardiovascular events in chronic kidney disease.Clinical kidney journal · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic kidney disease (CKD) is associated with high rates of cardiovascular events. We here explored whether the recently described triglycerides-glucose index (TyG) predicted the incidence of major adverse cardiovascular events (MACE) in these patients. Methods: This observationa study was undertaken of 1142 persons with CKD and free from diabetes and 460 controls from the prospective NEFRONA study. The study exposure was the TyG index at cohort inclusion. The study outcome was MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for unstable angina). Covariates included demographics, comorbidities, lipid profile, renal function and glycaemic control. Cox regression models evaluated the association between TyG index and 4-point MACE in patients with CKD. Results: TyG was higher [median 8.63 (interquartile range 8.32-8.95)] in patients with CKD compared with controls (P < 0.001). TyG increased across albuminuria categories but was similar for glomerular filtration rate categories among patients with CKD stages 3-5. During 46 ± 13 months of follow-up, 49 (4.3%) MACE were registered. TyG predicted the occurrence of MACE {hazard ratio (HR) 1.95 [95% confidence interval (CI) 1.11-3.40] per TyG unit increase; and HR 2.29 (95% CI 1.24-4.20] for TyG values above the median of 8.63 units}. Sensitivity analysis for subgroups of participants according to age, kidney function, body mass index and imaging evidence of atherosclerosis yielded similar results, as did adjusted analysis. Neither triglycerides nor glucose alone was associated with MACE. Conclusions: The TyG index is associated with the occurrence of major cardiovascular events in persons free from diabetes with non-dialysis dependent CKD.
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