Evidence map›Paper›PMID 36003603›Full record

ArticleCurrent research in insect science2021

Nicolas Salcedo-Porras, Shireen Noor, Charley Cai, Pedro L Oliveira, Carl Lowenberger

Open access · hybridAbstract read
In one paragraph

Article in Current research in insect science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Pathogens (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Interaction ofMicroorganisms · 2024
    Review
  7. Review
  8. Biomedicines · 2024
    Article
  9. Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cells · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nicolas Salcedo-PorrasCentre for Cell Biology, Development and Disease, Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Shireen NoorCentre for Cell Biology, Development and Disease, Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Charley CaiCentre for Cell Biology, Development and Disease, Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Pedro L OliveiraInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Ilha do Fundão, Rio de Janeiro, Brazil.
Carl LowenbergerCentre for Cell Biology, Development and Disease, Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Simon Fraser University · CAUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insects rely on an innate immune system to recognize and eliminate pathogens. Key components of this system are highly conserved across all invertebrates. To detect pathogens, insects use Pattern recognition receptors (PRRs) that bind to signature motifs on the surface of pathogens called Pathogen Associated Molecular Patterns (PAMPs). In general, insects use peptidoglycan recognition proteins (PGRPs) in the Immune Deficiency (IMD) pathway to detect Gram-negative bacteria, and other PGRPs and Gram-negative binding proteins (GNBPs) in the Toll pathway to detect Gram-positive bacteria and fungi, although there is crosstalk and cooperation between these and other pathways. Once pathogens are recognized, these pathways activate the production of potent antimicrobial peptides (AMPs). Most PRRs in insects have been reported from genome sequencing initiatives but few have been characterized functionally. The initial studies on insect PRRs were done using established dipteran model organisms such as

Indexed as

AMP, Antimicrobial PeptideAntimicrobial peptidescRHIM, cryptic RIP Homotypic Interaction MotifGNBP, Gram-negative Binding ProteinGr-, Gram-negativeGr+, Gram-positiveIMD, Immune DeficiencyIMD pathwayInnate immunityML, Maximum LikelihoodPAMP, Pathogen-Associated Molecular PatternPGN, PeptidoglycanPGRPPGRP, Peptidoglycan Recognition ProteinPRR, Pattern Recognition ReceptorRHIMRNAi, RNA interferenceSMOC, Supramolecular Organizing CentresTPM, Transcripts Per MillionTriatomines

Identifiers

PMID36003603
PMCPMC9387487
OpenAlexW3111940417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.