ArticleJTCVS open2022
Biomechanics in ascending aortic aneurysms correlate with tissue composition and strength.
Article in JTCVS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Bulk density-calibrated fiber networks reveal local weakness as the driver of protease-dependent aortic failure.International journal of engineering science · 2026Article
- Reduced mechanical strength correlates with decreased elastin content in aortic intima-media tissue: association with dissection in human ascending aortas.Medical & biological engineering & computing · 2026Article
- Computed tomography-derived elastic modulus as a noninvasive marker of aortic wall integrity: Correlation with histopathology in the ascending aorta.JTCVS open · 2026Article
- Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants.The Journal of physiology · 2025Article
- Magnetic resonance imaging-based hemodynamic wall shear stress alters aortic wall tissue biomechanics in bicuspid aortic valve patients.The Journal of thoracic and cardiovascular surgery · 2024Article
- Layer-specific biomechanical and histological properties of normal and dissected human ascending aortas.Heliyon · 2024Article
- From Biomechanical Properties to Morphological Variations: Exploring the Interplay between Aortic Valve Cuspidity and Ascending Aortic Aneurysm.Journal of clinical medicine · 2024Article
- Article
- Biomechanical properties of the aortic root are distinct from those of the ascending aorta in both normal and aneurysmal states.JTCVS open · 2023Article
- Thoracic Aortic Aneurysm Risk Assessment: A Machine Learning Approach.JACC. Advances · 2023Article
- Lengthwise regional mechanics of the human aneurysmal ascending thoracic aorta.Acta biomaterialia · 2023Article
- Searching for a physiologically meaningful parameter for aortic biomechanics-is energy loss the way?JTCVS open · 2022Article
- Reply from authors: Toward physiologically meaningful biomechanical parameters from ex vivo biaxial testing.JTCVS open · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Objective: This study correlates low strain tangential modulus (LTM) and transition zone onset (TZo) stress, biomechanical parameters that occur within the physiological range of stress seen in vivo, with tissue strength and histopathologic changes in aneurysmal ascending aortic tissue. Method: Ascending aortic aneurysm tissue samples were collected from 41 patients undergoing elective resection. Samples were subjected to planar biaxial testing to quantify LTM and TZo. These were then correlated with strength assessed from uniaxial testing and with histopathologic quantification of pathologic derangements in elastin, collagen, and proteoglycan (PG). Results: Decreased LTM and TZo were correlated with reduced strength ( Conclusions: LTM and TZo are correlated with common biomechanical and histopathologic alterations in ascending aortic aneurysm tissue that are thought to relate to the risk of acute aortic syndromes. LTM and TZo are measured under conditions approximating in vivo physiology and have the potential to be obtained noninvasively using medical imaging techniques. Therefore, they represent parameters that warrant future study as potential contributors to our growing knowledge of pathophysiology, disease progression, and risk stratification of aortic disease.
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