Evidence map›Paper›PMID 36003400›Full record

ArticleFrontiers in immunology2022

Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.

Yu Chen, Jialin He, Rui Chen, Zeyu Wang, Ziyu Dai, Xisong Liang, Wantao Wu, Peng Luo, Jian Zhang, Yun Peng and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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  5. Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Yu ChenDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jialin HeDepartment of Neurology, The Second Xiangya Hospital of Central South University, Changsha, China.
Rui ChenDepartment of Neurosurgery, Affiliated Nanhua Hospital, University of South China, Changsha, China.
Zeyu WangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Ziyu DaiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Xisong LiangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Wantao WuNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Peng LuoDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Changsha, China.
Jian ZhangDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Changsha, China.
Yun PengDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
Nan ZhangOne-third Lab, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Zaoqu LiuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou, Changsha, China.
Liyang ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Hao ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Quan ChengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNFirst Affiliated Hospital of Zhengzhou University · CNSouthern Medical University · CNHarbin Medical University · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aberrant protein disulfide isomerase A5 (PDIA5) expression was relevant to the poor prognosis of patients with human cancers. However, its relationship with the epigenetic and genetic alterations and its effect on tumor immunity is still lacking. In the present study, we comprehensively analyzed the immune infiltration role of PDIA5 in human cancers based on large-scale bioinformatics analyses and

Indexed as

GlioblastomaProtein Disulfide-IsomerasesAnimalsDNA MethylationHumansImmunotherapyMacrophagesMicePDIA5 protein, humanPdia5 protein, mouseProtein Disulfide-Isomerasesbioinformaticscancer immunotherapypan-cancer analysisprotein disulfide isomerase A5single-cell RNA sequencing

Identifiers

PMID36003400
PMCPMC9393377
OpenAlexW4290547601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.