Evidence map›Paper›PMID 36003380›Full record

ArticleFrontiers in immunology2022

Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice

Liuyue Yang, Weihua Ding, Yuanlin Dong, Cynthia Chen, Yanru Zeng, Zhangjie Jiang, Shuyuan Gan, Zerong You, Yilin Zhao, Yiying Zhang and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  15. Impact of gut microbiota on endometriosis: linking physical injury to mental health.Frontiers in cellular and infection microbiology · 2025
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Liuyue YangCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Weihua DingDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yuanlin DongDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Cynthia ChenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yanru ZengDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Zhangjie JiangDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Shuyuan GanDepartment of Anesthesiology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Zerong YouDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yilin ZhaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yiying ZhangDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Xinghua RenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Shiyu WangDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jiajia DaiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Zhong ChenCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Shengmei ZhuDepartment of Anesthesiology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Lucy ChenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Shiqian ShenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jianren MaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Zhongcong XieDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · USFirst Affiliated Hospital Zhejiang University · CNZhejiang Chinese Medical University · CN

Funding

Pathogenesis of Postoperative Cognitive DysfunctionR01AG041274 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongcong Xie, Guang Yang · 2012 to 2026
$6.7M
Postoperative Delirium and Alzheimer's Disease Related DementiasR01AG062509 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2019 to 2023
$3.7M
Gut Microbiota Influences Postoperative Cognitive Dysfunction through Indole-3-Propionic AcidR35GM128692 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2018 to 2022
$2.2M
General Anesthesia and Alzheimer's Disease NeuropathogenesisRF1AG070761 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2020 to 2020
$1.9M
Gut Microbiota Underlies the Heterogeneity of Aging Brain's Susceptibility to Postoperative DeliriumRF1AG070141 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN, WANG, CHANGNING · 2021 to 2021
$1.7M
Microbiome Dysbiosis and Postoperative Delirium PathogenesisR21AG065606 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN, ZHANG, YIYING · 2020 to 2020
$459k
NIA NIH HHS R01 AG041274NIA NIH HHS R01 AG062509NIA NIH HHS R21 AG065606NIA NIH HHS RF1 AG070141NIA NIH HHS RF1 AG070761NIGMS NIH HHS R35 GM128692
6 · The paper itself

Abstract

Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium

Indexed as

DeliriumElectroacupunctureGastrointestinal MicrobiomeAnimalsDendritic SpinesMicePaindeliriumdendritic spineelectroacupuncturegut microbiotamicemicrogliasurgical pain

Identifiers

PMID36003380
PMCPMC9393710
OpenAlexW4290613414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.