Evidence map›Paper›PMID 36003375›Full record

ArticleFrontiers in immunology2022

CD19+ lineage chimerism, an early biomarker after anti-CD19 CAR-T cell therapy in patients previously receiving a hematopoietic stem cell transplantation.

Isabel Martínez-Romera, Víctor Galán-Gómez, Berta González-Martínez, Pilar Guerra García, Sonsoles San Román Pacheco, Dolores Corral Sánchez, Yasmina Mozo Del Castillo, David Bueno Sánchez, Luisa Sisinni, Alba González Guerrero and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Isabel Martínez-RomeraPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Víctor Galán-GómezPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Berta González-MartínezPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Pilar Guerra GarcíaPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Sonsoles San Román PachecoPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Dolores Corral SánchezPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Yasmina Mozo Del CastilloPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
David Bueno SánchezPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Luisa SisinniPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Alba González GuerreroPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Serafin Castellano DámasoPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Elena Sánchez ZapardielImmunology Department, La Paz University Hospital, Madrid, Spain.
Beatriz Ruz CaracuelInstitute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain.
Antonio Balas PérezCenter of Blood Transfusion, Madrid, Spain.
Antonio Pérez-MartínezPediatric Hematology and Oncology Department, La Paz University Hospital, Madrid, Spain.
Hospital Universitario La Paz · ESUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment targeting CD19 by a chimeric antigen receptor expressed on T cells (anti-CD19 CAR-T) has led to a breakthrough in the management and treatment of relapsed and refractory B- cell acute lymphoblastic leukemia (B-ALL). After infusion, the efficacy of anti-CD19 CAR-T is monitored by bone marrow negative minimal residual disease and the absence of peripheral CD19

Indexed as

Antigens, CD19ChimerismImmunotherapy, AdoptiveReceptors, Chimeric AntigenHematopoietic Stem Cell TransplantationHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRecurrenceAntigens, CD19Receptors, Chimeric AntigenbiomarkerCAR-T cell therapyhematopoietic stem cell (HSC) transplantationlineage chimerismpediatric acute lymphoblastic leukemia (ALL)

Identifiers

PMID36003375
PMCPMC9393474
OpenAlexW4292200358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.