ReviewCureus2022
Hypothyroidism and Depression: A Narrative Review.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Biological rhythms in premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.BMC women's health · 2024Pooled it
- The Effect of Progressive Muscle Relaxation Technique on Fatigue and Depression in Patients With Hypothyroidism: A Randomized Controlled Trial.Health science reports · 2026Article
- The complex relationship between endocrine and psychiatric disorders: an epidemiological study of risk estimates.Medicine and pharmacy reports · 2026Article
- Alternative and Complementary Therapies: A Review Exploring the Role of Yoga and Ayurveda-based Herbal Medicines in Alleviating Hypothyroidism and Its Neuropsychiatric Manifestations.Annals of neurosciences · 2026Review
- Review
- Impact of Levothyroxine Treatment for Hypothyroidism on the Risk of Psychiatric Interventions in Children and Adolescents with Anxiety Disorders: A Retrospective Analysis of Data from the TriNetX Platform.Journal of clinical medicine · 2026Article
- The association between thyroid hormone levels and psychiatric symptoms in patients with mania or depression.Endocrine journal · 2026Article
- Identification of DIO2 as a Molecular Therapeutic Target for Depression in Chronic Rhinosinusitis: A Comprehensive Bioinformatics and Experimental Study.Biochemical genetics · 2026Article
- Natural product-based interventions for thyroid disorders: mechanisms and applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults.Frontiers in psychiatry · 2026Article
- Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study.Bioinformation · 2026Article
- Dietary inflammatory potential in depressive symptoms in older Chinese people in Hong Kong: a cohort study.Frontiers in nutrition · 2026Article
- Gestational PFAS concentrations in association with maternal depression and perceived stress during pregnancy and postpartum in the ECHO cohort.Environmental research · 2025Article
- Unmasking the cycle: Premenstrual and menstrual exacerbation of psychiatric disorders and impact on female mental health.World journal of psychiatry · 2025Review
- Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients.BMC psychiatry · 2025Article
- Association Between Hypothyroidism and Depression in Individuals with Down Syndrome: A Retrospective Analysis.Life (Basel, Switzerland) · 2025Article
- Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosa.Brain and behavior · 2025Article
- Sexual Functioning and Depressive Symptoms in Levothyroxine-Treated Women with Postpartum Thyroiditis and Different Vitamin D Status.Nutrients · 2025Article
- Incidence and risk factors of hypothyroidism in psychiatric outpatients with long-term lithium treatment: a 10-year retrospective hospital-based study.Annals of general psychiatry · 2025Article
- Association of Sexual Dysfunction, Vitamin D, and Thyroid Levels with Suicidal Behavior Among Patients with Depressive Disorder: A Cross-sectional Study.Indian journal of psychological medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been an established relationship between hypothyroidism and depression. Studies have demonstrated that somatostatin and serotonin influence the hypothalamus-pituitary-thyroid axis, which links hypothyroidism to depression. Multiple studies concluded that undiagnosed, untreated, undertreated patients with hypothyroidism are at increased risk of developing depression. Autoimmune thyroiditis is also associated with an increased risk of depression. Elevated thyroid-stimulating hormone (TSH), antithyroglobulin (TgAb), and thyroid peroxidase antibodies (TPOAb) levels have all been linked to depression and an increased risk of suicide. Moreover, hypothyroidism is known to be one of the leading causes of treatment-resistant depression. Treating underlying hypothyroidism with thyroid replacement therapy could significantly improve mood disorders such as depression. Levothyroxine therapy is also used as adjunctive therapy to antidepressants in the management of depression, and it is known to improve the symptoms of depression rapidly when compared to antidepressants alone. This review strengthens the link between hypothyroidism and depression, and it also demonstrates how treating the underlying hypothyroidism in people who have been diagnosed with depression will be very beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.