ReviewFrontiers in genetics2022
Harnessing the potential of bulk segregant analysis sequencing and its related approaches in crop breeding.
Review in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Advances in mutant characterization for detecting causal mutations in crop plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Multi-Omics Integration Unravels the Genetic and Hormonal Regulatory Mechanisms Underlying Increased Main Stem Node Number in Soybean.Plants (Basel, Switzerland) · 2026Article
- Identification and Fine-Mapping ofInternational journal of molecular sciences · 2026Article
- Identifying Candidate Genes for Cotton Fruit Branch Length Using BSA-Seq and RNA-Seq.Plants (Basel, Switzerland) · 2026Article
- Development and validation of KASP markers for powdery mildew resistance in Korean naked barley using QTL-seq.Molecular breeding : new strategies in plant improvement · 2026Article
- Identification of candidate regions associated with resistance to early blight in tomato (Solanum lycopersicum L.) using BSA-seq.Journal of applied genetics · 2026Article
- QTL-Seq Identifies Extra QTLs and Candidate Genes Controlling High Haploid Induction Rate in Maize.Plants (Basel, Switzerland) · 2026Article
- Reverse BSA-QTLseq: A new genotype-driven bioinformatics approach for simultaneous trait mapping.Plant communications · 2026Article
- Digital morphological data can generate accurate pre-emergence herbicide dose-response curves inFrontiers in plant science · 2026Article
- The Harpin-Induced Hypersensitive Reaction in Nicotiana tabacum Requires Wall-Associated Kinase 2.Molecular plant pathology · 2025Article
- Yield and yield component trait analysis with DArT genotyping for GWAS in soybean grown in drought conditions of Kazakhstan.Frontiers in plant science · 2025Article
- Identification of QTLs and Key Genes Enhancing Lodging Resistance in Soybean Through Chemical and Physical Trait Analysis.Plants (Basel, Switzerland) · 2024Article
- Combined BSA-Seq and RNA-Seq Analysis to Identify Candidate Genes Associated with Aluminum Toxicity in Rapeseed (International journal of molecular sciences · 2024Article
- Fine mapping and identification of ERF transcription factor ERF017 as a candidate gene for cold tolerance in pumpkin.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Refining flowering date enhances sesame yield independently of day-length.BMC plant biology · 2024Article
- Mapping and Omics Integration: Towards Precise Rice Disease Resistance Breeding.Plants (Basel, Switzerland) · 2024Review
- QTL-Seq identified a genomic region on chromosome 1 for soil-salinity tolerance in FFrontiers in plant science · 2024Article
- Conjunctive Analyses of BSA-Seq and BSR-Seq to Identify Candidate Genes Controlling the Black Lemma and Pericarp Trait in Barley.International journal of molecular sciences · 2023Article
- Applications of Artificial Intelligence in Climate-Resilient Smart-Crop Breeding.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most plant traits are governed by polygenes including both major and minor genes. Linkage mapping and positional cloning have contributed greatly to mapping genomic loci controlling important traits in crop species. However, they are low-throughput, time-consuming, and have low resolution due to which their efficiency in crop breeding is reduced. In this regard, the bulk segregant analysis sequencing (BSA-seq) and its related approaches, viz., quantitative trait locus (QTL)-seq, bulk segregant RNA-Seq (BSR)-seq, and MutMap, have emerged as efficient methods to identify the genomic loci/QTLs controlling specific traits at high resolution, accuracy, reduced time span, and in a high-throughput manner. These approaches combine BSA with next-generation sequencing (NGS) and enable the rapid identification of genetic loci for qualitative and quantitative assessments. Many previous studies have shown the successful identification of the genetic loci for different plant traits using BSA-seq and its related approaches, as discussed in the text with details. However, the efficiency and accuracy of the BSA-seq depend upon factors like sequencing depth and coverage, which enhance the sequencing cost. Recently, the rapid reduction in the cost of NGS together with the expected cost reduction of third-generation sequencing in the future has further increased the accuracy and commercial applicability of these approaches in crop improvement programs. This review article provides an overview of BSA-seq and its related approaches in crop breeding together with their merits and challenges in trait mapping.
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