Evidence map›Paper›PMID 36003210›Full record

ReviewJournal of clinical and translational science2022

Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies.

E M Smith, E E Anderson, R Deer, J Prochaska, K Bohn, S Croisant

Abstract readReview
In one paragraph

Review in Journal of clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E M SmithSchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0002-4615-8204
E E AndersonLoyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
R DeerSchool of Health Professions, University of Texas Medical Branch, Galveston, TX, USA.
J ProchaskaSchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
K BohnInstitute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA.
S CroisantSchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA.

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
NCATS NIH HHS UL1 TR001439NCATS NIH HHS UL1 TR002003
6 · The paper itself

Abstract

Fair inclusion of research subjects is necessary to ensure that post-acute sequelae COVID-19 (PASC) research results benefit all members of society. Scientists should conduct research on a broad sample of individuals who represent clinically relevant factors influencing a disease. Without demographic diversity and sociological and environmental variability, research outputs are less likely to apply to different populations and would thus increase health disparities. The goal of this narrative literature review and ethical analysis is to apply fair selection criteria to PASC research studies. We briefly highlight the importance of fair subject selection in translational research and then identify features of PASC, as well as PASC research, that hinder fair inclusion of research participants. We will demonstrate that determining an adequate and representative sample is not simply a matter of ensuring greater diversity; rather, fairness requires a broader evaluation of risks, burdens, and benefits specific to underrepresented populations. We provide recommendations to ensure fair subject selection in PASC research and promote translation toward positive health outcomes for all individuals, including the most vulnerable.

Indexed as

diversityfair inclusionfair subject selectionPost sequelae COVID-19representation in researchresearch ethics

Identifiers

PMID36003210
PMCPMC9389279

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.