ReviewCurrent epidemiology reports2022
The Utility of Multistate Models: A Flexible Framework for Time-to-Event Data.
Review in Current epidemiology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Variable Selection via Fused Sparse-Group Lasso Penalized Multi-state Models Incorporating Molecular Data.Biometrical journal. Biometrische Zeitschrift · 2025Trial
- A pharmacometric multistate model for predicting long-term treatment outcomes of patients with pulmonary TB.The Journal of antimicrobial chemotherapy · 2024Trial
- Predicting disease progression and mortality in prostate cancer using real-world data-driven time-inhomogeneous Markov models.iScience · 2026Article
- The Effect of Polycystic Ovarian Syndrome on Development of Diabetes Mellitus by a Multistate Modelling Approach.Endocrinology, diabetes & metabolism · 2026Article
- Associations of cognitive impairment and physical disability with the risk and reversibility of depressive symptoms in Chinese older adults.BMC geriatrics · 2026Observational
- A stakeholder-inclusive conceptual framework for modeling routinely collected health data for therapeutic decision-making illustrated by means of multistate models.BMC medical research methodology · 2026Article
- Diet quality and progression from health to chronic disease, multimorbidity and mortality in the UK Biobank.BMC medicine · 2026Article
- Racial Differences in Secondary Treatment Pathways and Survival in Localized Prostate Cancer.JAMA network open · 2026Article
- Life-course body size trajectories and the progression of cardio-renal-metabolic multimorbidity: a prospective UK biobank study.Nutrition & metabolism · 2026Article
- Smoking hot joint models for attrition bias-XMAR-ks the spot.American journal of epidemiology · 2026Article
- How Changes in Functional Disability Are Associated With Living Arrangements for Chinese Older Adults: Results From a Longitudinal Study (2008-2018).Australasian journal on ageing · 2026Article
- Evaluating the optimal duration of medication treatment for opioid use disorder.Addiction (Abingdon, England) · 2026Article
- Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis-inflammatory bowel disease cohort.Hepatology (Baltimore, Md.) · 2026Article
- Ambient Air Pollution and COVID-19 in California.Research report (Health Effects Institute) · 2026Article
- Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making: ENGAGE AF-TIMI 48 Trial Analysis.JACC. Advances · 2026Article
- PrEParing for Long-acting Technologies: A Multistate Analysis of PrEP Persistence and HIV and STI Lab Coverage Among Oral PrEP Initiators in St. Louis, Missouri (2014-2021).Open forum infectious diseases · 2026Article
- Differential associations of non-chronic and chronic pain with dementia risk: insights from a cohort study.Frontiers in neuroscience · 2026Article
- Oral Frailty, Dental Visits, and Healthy Life Expectancy: A 6-Year Prospective Cohort Among Japanese Older Adults.Geriatrics & gerontology international · 2025Article
- Constipation in a Large Online Cohort of Persons with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Identifying Important Factors for Depressive Symptom Dynamics in Chinese Middle-Aged and Older Adults Using a Multi-State Transition Model with Feature Selection.Behavioral sciences (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Purpose of Review: Survival analyses are common and essential in medical research. Most readers are familiar with Kaplan-Meier curves and Cox models; however, very few are familiar with multistate models. Although multistate models were introduced in 1965, they only recently receive more attention in the medical research community. The current review introduces common terminologies and quantities that can be estimated from multistate models. Examples from published literature are used to illustrate the utility of multistate models. Recent Findings: A figure of states and transitions is a useful depiction of a multistate model. Clinically meaningful quantities that can be estimated from a multistate model include the probability in a state at a given time, the average time in a state, and the expected number of visits to a state; all of which describe the absolute risks of an event. Relative risk can also be estimated using multistate hazard models. Summary: Multistate models provide a more general and flexible framework that extends beyond the Kaplan-Meier estimator and Cox models. Multistate models allow simultaneous analyses of multiple disease pathways to provide insights into the natural history of complex diseases. We strongly encourage the use of multistate models when analyzing time-to-event data. Supplementary Information: The online version contains supplementary material available at 10.1007/s40471-022-00291-y.
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