Evidence map›Paper›PMID 36002966›Full record

ArticleNeuroImage. Clinical2022

Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms.

Nawroz Barazanji, J Paul Hamilton, Adriane Icenhour, Rozalyn A Simon, Olga Bednarska, Sofie Tapper, Anders Tisell, Peter Lundberg, Maria Engström, Susanna Walter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Interoceptive Processing in Functional Gastrointestinal Disorders.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nawroz BarazanjiDepartment of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Sweden; Department of Gastroenterology, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden. Electronic address: Nawroz.Barazanji@liu.se.
J Paul HamiltonCenter for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Adriane IcenhourDepartment of Medical Psychology and Medical Sociology, Ruhr University Bochum, Bochum, Germany.
Rozalyn A SimonCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Olga BednarskaDepartment of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Sweden; Department of Gastroenterology, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Sofie TapperCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Radiation Physics, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Anders TisellCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Radiation Physics, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Peter LundbergCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Radiation Physics, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Maria EngströmCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Susanna WalterDepartment of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Sweden; Department of Gastroenterology, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Linköping University · SERuhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIrritable bowel syndrome (IBS) is a chronic pain disorder characterized by disturbed interactions between the gut and the brain with depression as a common comorbidity. In both IBS and depression, structural brain alterations of the insular cortices, key structures for pain processing and interoception, have been demonstrated but the specificity of these findings remains unclear. We compared the gray matter volume (GMV) of insular cortex (IC) subregions in IBS women and healthy controls (HC) and examined relations to gastrointestinal (GI) symptoms and glutamate + glutamine (Glx) concentrations. We further analyzed GMV of IC subregions in women with major depression (MDD) compared to HC and addressed possible differences between depression, IBS, IBS with depression and HC.

designWomen with IBS (n = 75), MDD (n = 41) and their respective HC (n = 39 and n = 43) underwent structural brain MRI. IC subregion volumes were estimated using statistical parametric mapping software. General linear model approaches were applied to IC volumetric data and FDR-corrected partial correlation analyses assessed relations between GMV, GI symptoms and Glx concentrations.

resultsIBS patients had significantly smaller IC subregions than HC in both hemispheres but there was no significant difference between MDD compared with IBS and HC for any insular subregion. In IBS, the dorsal anterior insular volumes were negatively correlated with symptoms of nausea and pain, and the left ventral subregion showed a positive correlation with straining to defecate, while the posterior subregion volumes showed no relation to symptoms. In the anterior insula, concentration of Glx showed positive correlations with GMV bilaterally in HC and with GMV of the right anterior insula in IBS.

conclusionAs the interoceptive cortex, the insula shows substantial and disease-specific structural differences in patients with chronic interoceptive visceral pain. Particularly changes in the anterior proportions might be related to chronic exposure to or enhanced salience towards adverse interoceptive visceral signals and could be linked to biochemical changes, calling for further multimodal and longitudinal work.

Indexed as

Irritable Bowel SyndromeCerebral CortexFemaleGray MatterHumansMagnetic Resonance ImagingPainBrain morphometryDepressionGray matter volumeGut-brain axisIBS symptomsInsula

Identifiers

PMID36002966
PMCPMC9421502
OpenAlexW4288069729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.