ArticleNeuroImage. Clinical2022
Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study.Journal of atherosclerosis and thrombosis · 2026Article
- Transcriptomic insights into the co-occurring psychological symptoms and cardiovascular risks among military service members and veterans with mild traumatic brain injury: A LIMBIC-CENC study.Brain, behavior, & immunity - health · 2026Article
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study.JMIR research protocols · 2025Article
- Racial and ethnic differences in cardiometabolic predictors of white matter hyperintensities burden among males: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2025Article
- Review
- WMH-DualTasker: A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction.Human brain mapping · 2025Article
- Gender-specific associations between neutrophil levels and refracture risks: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Exploration of heterogeneity in risk factors associated with imaging subtypes of white matter hyperintensities on fluid-attenuated inversion recovery magnetic resonance imaging.Frontiers in neurology · 2025Article
- Serum albumin and white matter hyperintensities.Translational psychiatry · 2024Article
- Association of vulnerable plaques with white matter hyperintensities on high-resolution magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Age-Accelerated Increase of White Matter Hyperintensity Volumes Is Exacerbated by Heavy Alcohol Use in People Living With HIV.Biological psychiatry · 2024Article
- Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer's Disease: Results from the HELIAD Study.Current issues in molecular biology · 2024Article
- The Relationship of MRI-Derived Alzheimer's and Cerebrovascular-Related Signatures With Level of and Change in Health and Financial Literacy.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Contribution of Conventional Cardiovascular Risk Factors to Brain White Matter Hyperintensities.Journal of the American Heart Association · 2023Article
- Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later.Frontiers in global women's health · 2023Article
- Diabetes mellitus exacerbates changes in white matter hyperintensity shapes and volume: A longitudinal study.Alzheimer's & dementia (New York, N. Y.)Article
- Features predicting data exclusion in imaging studies of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with a more irregular shape of periventricular/confluent WMH (convexity (B (95 % CI)): -0.12 (-0.22--0.03); concavity index: 0.06 (0.02-0.11)), but not with total WMH volume (0.22 (-0.15-0.59)). Presence of diabetes was associated with deep WMH volume (0.89 (0.15-1.63)). Body mass index or hyperlipidemia showed no association with WMH markers. In conclusion, different cardiovascular risk factors seem to be related to a distinct pattern of WMH shape markers in non-demented older adults. These findings may suggest that different underlying cardiovascular pathological mechanisms lead to different WMH MRI phenotypes, which may be valuable for early detection of individuals at risk for stroke and dementia.
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