Evidence map›Paper›PMID 36002956›Full record

Trial reportNeuroImage. Clinical2022

Regional brain volume prior to treatment is linked to outcome after cognitive rehabilitation in traumatic brain injury.

Alexander Olsen, Emily L Dennis, Jan Stubberud, Elizabeth S Hovenden, Anne-Kristin Solbakk, Tor Endestad, Per Kristian Hol, Anne-Kristine Schanke, Marianne Løvstad, Sveinung Tornås

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02692352 (Cognitive Rehabilitation of Executive Dysfunction - Goal Management Training in Patients With Acquired Brain Injury), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02692352 nacompletednot on this map

Cognitive Rehabilitation of Executive Dysfunction - Goal Management Training in Patients With Acquired Brain Injury

TypeinterventionalSponsorSunnaas Rehabilitation HospitalRan2012 to 2014Enrolled70ConditionsBrain InjuriesArmsGoal Management Training, Brain Health Workshop
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Alexander OlsenDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address: alexander.olsen@ntnu.no.
Emily L DennisDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Veteran Affairs Medical Center, Salt Lake City UT, USA.
Jan StubberudDepartment of Psychology, University of Oslo, Oslo, Norway; Department of Research, Lovisenberg Diaconal Hospital, Oslo, Norway; Department of Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Elizabeth S HovendenDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Veteran Affairs Medical Center, Salt Lake City UT, USA.
Anne-Kristin SolbakkRITMO, Department of Psychology, University of Oslo, Norway; Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Norway; Department of Neuropsychology, Helgeland Hospital, 8657 Mosjøen, Norway.
Tor EndestadRITMO, Department of Psychology, University of Oslo, Norway; Department of Neuropsychology, Helgeland Hospital, 8657 Mosjøen, Norway.
Per Kristian HolThe Intervention Centre, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
Anne-Kristine SchankeDepartment of Psychology, University of Oslo, Oslo, Norway; Department of Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Marianne LøvstadDepartment of Psychology, University of Oslo, Oslo, Norway; Department of Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Sveinung TornåsDepartment of Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Sunnaas sykehus · NOOslo University Hospital · NOUniversity of Oslo · NOGeorge E. Wahlen Department of VA Medical Center · USSt Olav's University Hospital · NOUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive rehabilitation is useful for many after traumatic brain injury (TBI), but we lack critical knowledge about which patients benefit the most from different approaches. Advanced neuroimaging techniques have provided important insight into brain pathology and systems plasticity after TBI, and have potential to inform new practices in cognitive rehabilitation. In this study, we aimed to identify candidate structural brain measures with relevance for rehabilitation of cognitive control (executive) function after TBI. Twenty-eight patients (9 female, mean age 40.5 (SD = 13.04) years) with TBI (>21 months since injury) that participated in a randomized controlled cognitive rehabilitation trial (NCT02692352) were included in the analyses. Regional brain volume was extracted from T1-weighted MRI scans before treatment using tensor-based morphometry. Both positive and negative associations between treatment outcome (everyday cognitive control function) and regional brain volume were observed. The most robust associations between regional brain volume and improvement in function were observed in midline fronto-parietal regions, including the anterior and posterior cingulate cortices. The study provides proof of concept and valuable insight for planning future studies focusing on neuroimaging in cognitive rehabilitation after TBI.

Indexed as

Brain Injuries, TraumaticAdultBrainCognitionExecutive FunctionFemaleHumansMagnetic Resonance ImagingNeuroimagingBrain injuryExecutive functionMagnetic resonance imagingPersonalized treatmentRehabilitation medicine

Identifiers

PMID36002956
PMCPMC9421497
OpenAlexW4288070093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.