Evidence map›Paper›PMID 36002928›Full record

ArticleAddiction (Abingdon, England)2023

Impacts of recreational cannabis legalization on cannabis use: a longitudinal discordant twin study.

Stephanie M Zellers, J Megan Ross, Gretchen R B Saunders, Jarrod M Ellingson, Jacob E Anderson, Robin P Corley, William Iacono, John K Hewitt, Christian J Hopfer, Matt K McGue and 1 more

Open access · hybridAbstract readTwin Study
In one paragraph

Article in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

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  7. Characteristics of Cannabis Use Among Head and Neck Cancer Survivors.Laryngoscope investigative otolaryngology · 2025
    Article
  8. Cannabis Use Among Older Adults.JAMA network open · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Stephanie M ZellersDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8927-3483
J Megan RossDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-4424-5301
Gretchen R B SaundersDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-5972-9785
Jarrod M EllingsonDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9932-2656
Jacob E AndersonDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
William IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Christian J HopferDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Matt K McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Scott VriezeDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USUniversity of Colorado Boulder · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Adolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4M
Training in genetic and neurobehavioral mechanisms of addictionT32DA050560 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Scott Ian Vrieze · 2020 to 2026
$2.0M
Changes in cognition and psychiatric disorder symptoms during cannabis abstinence using a novel discordant twin designK23DA054212 · NIDA · UNIVERSITY OF COLORADO DENVER · PI ROSS, JESSICA MEGAN · 2021 to 2025
$1.0M
NIAAA NIH HHS R37 AA009367NIDA NIH HHS K23 DA054212NIDA NIH HHS L30 DA054523NIDA NIH HHS T32 DA050560
6 · The paper itself

Abstract

aimsTo estimate the effect of recreational legalization on cannabis use frequency and sources of variance across legal environments.

designLongitudinal discordant twin and gene-environment interaction models in twins recruited from birth records and assessed prospectively.

settingThe United States, including states with different recreational cannabis policies before and after 2014, when recreational cannabis was first legalized.

participantsTwo longitudinal, prospectively assessed samples of American twins aged 24-47 (n = 1425 in legal states, n = 1996 in illegal states), including 111 monozygotic pairs discordant for residence. MEASUREMENTS: Current cannabis use frequency (measured continuously and ordinally) was the primary outcome, and the predictor was recreational status of cannabis (legal/illegal) in the participant's state of residence at the time of assessment. Covariates include age, sex and cannabis use frequency prior to 2014.

findingsAccounting for pre-2014 use, residents of legal states used cannabis more frequently than residents of illegal states (b = 0.21, P = 8.08 × 10

conclusionsIn the United States, there appears to be a ~ 20% average increase in cannabis use frequency attributable to recreational legalization, consistent across increasingly rigorous designs. In addition, the heritability of cannabis use frequency appears to be moderated by legalization.

Indexed as

CannabisMarijuana SmokingMarijuana UseHumansLegislation, DrugLongitudinal StudiesUnited StatesBehavior geneticscausal inferenceco-twin controlgene-environment interactionnatural experimentsubstance use

Identifiers

PMID36002928
PMCPMC10086942
OpenAlexW4293102929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.