Evidence map›Paper›PMID 36002666›Full record

ArticleBiochemical genetics2023

Circ_HIPK3 Inhibits H

Sihui Chen, Minghong Wang, Rui Jian, Hui Li, Guoli Liu, Cuiyun Zhou, Yan Xiong, Wenqian Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sihui Chen *Department of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Minghong Wang *Department of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Rui JianDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Hui LiDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Guoli LiuDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Cuiyun ZhouDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Yan XiongDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China.
Wenqian WangDepartment of Ophthalmology, Jingmen No.1 People's Hospital, No. 168, Xiangshan Avenue, Duodao District, Jingmen, 448000, China. wangwenqian1314@163.com.ORCID http://orcid.org/0000-0001-6534-0311
First People’s Hospital of Jingmen · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related cataract (ARC) is one of the most common chronic diseases. Circular RNA (circ)_HIPK3 is reported to be involved in the advancement of ARC, but its molecular mechanism has not been clarified. Our study provides a new perspective on the clinical treatment of ARC. Our data showed that the expression levels of circ_HIPK3 and histone deacetylase 4 (HDAC4) were downregulated, while microRNA (miR)-495-3p level was increased in ARC tissues and H

Indexed as

CataractMicroRNAsApoptosisCell ProliferationEpithelial CellsHistone DeacetylasesHumansHydrogen PeroxideIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRepressor ProteinsRNA, CircularHDAC4 protein, humanHIPK3 protein, humanHistone DeacetylasesHydrogen PeroxideIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN495 microRNA, humanProtein Serine-Threonine KinasesRepressor ProteinsRNA, CircularAge-related cataractcirc_HIPK3HDAC4miR-495-3p

Identifiers

PMID36002666
OpenAlexW4293005068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.