Evidence map›Paper›PMID 36002591›Full record

ArticleActa diabetologica2022

Early marker of ocular neurodegeneration in children and adolescents with type 1 diabetes: the contributing role of polymorphisms in mir146a and mir128a genes.

Claudia Piona, Silvia Costantini, Chiara Zusi, Tiziano Cozzini, Emilio Pedrotti, Marco Marigliano, Elena Fornari, Alice Maguolo, Anita Morandi, Claudio Maffeis

Open access · hybridAbstract read
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Article in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Claudia PionaSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Silvia CostantiniSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Chiara ZusiSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Tiziano CozziniDepartment of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, P.le L. A. Scuro 10, 37134, Verona, Italy.
Emilio PedrottiDepartment of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, P.le L. A. Scuro 10, 37134, Verona, Italy.
Marco MariglianoSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Elena FornariSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Alice MaguoloSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
Anita MorandiSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy. anita.morandi@univr.it.ORCID http://orcid.org/0000-0002-2631-9330
Claudio MaffeisSection of Pediatric Diabetes and Metabolism, Department of Surgery, Dentistry, Pediatrics, and Gynecology, University of Verona, Verona, P.le Stefani 1, 37126, Verona, Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly ocular neurodegenerative signs of diabetic neuropathy (DN) can be found in children and adolescents with type 1 diabetes (T1D). No data are available on the potential role of polymorphisms in miRNAs genes in predisposing T1D subjects to these signs.

aimsTo determine whether MIR146A rs2910164 and MIR128A rs11888095 polymorphisms are associated with early retinal and corneal neurodegenerative changes in pediatric patients with T1D.

methodsA total of 140 T1D children/adolescents underwent spectral domain-optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM) with measurement of retinal and corneal nerve fiber parameters. Risk factors for diabetes complications (diabetes duration, blood pressure, HbA1c) were recorded. Genotyping of rs2910164 and rs1188095 SNPs and genotype-phenotype association analysis were performed.

resultsThe C allele of rs2910164 in MIR146A was associated with higher values of IVCM parameters and minimum rim width (MRW) of the peripapillary region of optic nerve head measured in the retina, whereas the T allele of rs1188095 in MIR128A was associated with a significant impairment of them. Multiple regression analysis showed that MIR146A and MIR128A polymorphisms were significantly associated with corneal nerve fiber length (beta = 0.225 and - 0.204, respectively) and other IVCM parameters, independently from age, diabetes duration, HbA1c and systolic blood pressure percentile. Similar results were found for MRW (beta = 0.213 and - 0.286, respectively).

conclusionsThese results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN.

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesEye DiseasesMicroRNAsNeurodegenerative DiseasesAdolescentBiomarkersChildGenetic Predisposition to DiseaseGlycated HemoglobinHumansPolymorphism, Single NucleotideTomography, Optical CoherenceBiomarkersGlycated HemoglobinMicroRNAsMIRN128 microRNA, humanMIRN146 microRNA, humanDiabetic neuropathyGenetic susceptibility,MicroRNAsMIR128A gene polymorphismMIR146A gene polymorphismOcular neurodegenerationType 1 diabetes

Identifiers

PMID36002591
PMCPMC9581843
OpenAlexW4293102529

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.