Evidence map›Paper›PMID 36002569›Full record

ArticleNature2022

Fos ensembles encode and shape stable spatial maps in the hippocampus.

Noah L Pettit, Ee-Lynn Yap, Michael E Greenberg, Christopher D Harvey

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 153 citations in OpenAlex.

  1. Article
  2. Article
  3. CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons.bioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Noah L PettitDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8699-7443
Ee-Lynn YapDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6537-508X
Michael E GreenbergDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. michael_greenberg@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1380-2160
Christopher D HarveyDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. harvey@hms.harvard.edu.ORCID http://orcid.org/0000-0001-9850-2268
Harvard University · US

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ZHIGANG HE · 1998 to 2026
$21.3M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
ELECTRICAL STIMULATION OF IMMEDIATE GENESR01NS028829 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GREENBERG, MICHAEL ELDON · 1990 to 2024
$6.2M
Toward mechanistic cognitive neuroscience: cell types, connectivity, and patterned perturbationsDP1MH125776 · NIMH · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D · 2020 to 2024
$5.9M
Parietal Cortex Networks for Sensorimotor Processing During NavigationR01NS089521 · NINDS · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D · 2015 to 2024
$4.5M
NEI NIH HHS P30 EY012196NICHD NIH HHS P50 HD105351NIMH NIH HHS DP1 MH125776NINDS NIH HHS R01 NS028829NINDS NIH HHS R01 NS089521
6 · The paper itself

Abstract

In the hippocampus, spatial maps are formed by place cells while contextual memories are thought to be encoded as engrams

Indexed as

HippocampusProto-Oncogene Proteins c-fosAnimalsCA1 Region, HippocampalCalciumMiceNeuronsPlace CellsCalciumFos protein, mouseProto-Oncogene Proteins c-fos

Identifiers

PMID36002569
PMCPMC9452297
OpenAlexW4293004892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.