Evidence map›Paper›PMID 36002317›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Hemithioindigo-Based Visible Light-Activated Molecular Machines Kill Bacteria by Oxidative Damage.

Ana L Santos, Alexis van Venrooy, Anna K Reed, Aaron M Wyderka, Víctor García-López, Lawrence B Alemany, Antonio Oliver, George P Tegos, James M Tour

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Flavonoid-RichMicroorganisms · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023
    Review
  11. Using theMicrobiology (Reading, England) · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ana L SantosDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.ORCID 0000-0002-5450-9414
Alexis van VenrooyDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.
Anna K ReedDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.ORCID 0000-0002-9703-9109
Aaron M WyderkaDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.
Víctor García-LópezDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.ORCID 0000-0003-2915-4591
Lawrence B AlemanyDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.ORCID 0000-0001-7451-1020
Antonio OliverIdISBA - Fundación de Investigación Sanitaria de las Islas Baleares, Palma, 07120, Spain.
George P TegosOffice of Research, Reading Hospital, Tower Health, 420 S. Fifth Avenue, West Reading, PA, 19611, USA.ORCID 0000-0002-3737-8491
James M TourDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.ORCID 0000-0002-8479-9328
Rice University · USHealth Research Institute of the Balearic Islands · ESReading Hospital · USWelch Foundation · US

Funding

Burroughs Wellcome FundCareer Award at the Scientific InterfaceDEVCOM Army Research Laboratory W911NF-18-2-0234Electron Microscopy FacilitiesEuropean Union's Horizon 2020Marie Skłodowska-Curie Actions 843116Rice UniversityRobert A. Welch Foundation C-2017-20190330The Discovery Institute
6 · The paper itself

Abstract

Antibiotic resistance is a growing health threat. There is an urgent and critical need to develop new antimicrobial modalities and therapies. Here, a set of hemithioindigo (HTI)-based molecular machines capable of specifically killing Gram-positive bacteria within minutes of activation with visible light (455 nm at 65 mW cm

Indexed as

Methicillin-Resistant Staphylococcus aureusAnimalsAnti-Bacterial AgentsBacteriaIndigo CarmineLightMammalsMicrobial Sensitivity TestsOxidative StressReactive Oxygen SpeciesStaphylococcus aureusAnti-Bacterial AgentshemithioindigoIndigo CarmineReactive Oxygen Speciesantibiotic resistanceGram-positive bacteriahemithioindigomolecular switches and motorsvisible light active

Identifiers

PMID36002317
PMCPMC9596824
OpenAlexW4293008979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.