Evidence map›Paper›PMID 36002154›Full record

ArticleThe FEBS journal2023

Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics.

Alberto Zavarise, Shruthi Sridhar, Tiila-Riikka Kiema, Rikkert K Wierenga, Mikael Widersten

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Novel aspects of ethylene glycol catabolism.Applied microbiology and biotechnology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alberto ZavariseDepartment of Chemistry - BMC, Uppsala University, Sweden.
Shruthi SridharDepartment of Chemistry - BMC, Uppsala University, Sweden.
Tiila-Riikka KiemaFaculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.
Rikkert K WierengaFaculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.
Mikael WiderstenDepartment of Chemistry - BMC, Uppsala University, Sweden.ORCID 0000-0002-3203-3793
Uppsala University · SEUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A group-III iron containing 1,2-propanediol oxidoreductase, FucO, (also known as lactaldehyde reductase) from Escherichia coli was examined regarding its structure-dynamics-function relationships in the catalysis of the NADH-dependent reduction of (2S)-lactaldehyde. Crystal structures of FucO variants in the presence or absence of cofactors have been determined, illustrating large domain movements between the apo and holo enzyme structures. Different structures of FucO variants co-crystallized with NAD

Indexed as

Alcohol OxidoreductasesNADAldehydesBinding SitesEscherichia coliHydrogen BondingKineticsAlcohol OxidoreductasesAldehydeslactaldehydelactaldehyde reductaseNADcatalytic mechanismcrystal structureslactaldehyde reductasestereoselectivity

Identifiers

PMID36002154
PMCPMC10087678
OpenAlexW4293105520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.