ArticleCancer science2022
Effectiveness of endoscopic screening for gastric cancer: The Japan Public Health Center-based Prospective Study.
Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries-A Systematic Review and Meta-Analysis.United European gastroenterology journal · 2025Pooled it
- Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Review
- KRAS Mutations in Duodenal Lavage Fluid After Secretin Stimulation for Detection of Pancreatic Cancer.Annals of surgery · 2026Article
- Sensitivity and specificity of endoscopic and radiographic screening for localized gastric cancer in a real-world, population-based setting.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Upper Gastrointestinal Endoscopy in Elderly Patients: An Individualized Decision-Making Approach for Screening and Surveillance.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- From screening to surveillance: integrated prevention ofThe Lancet regional health. Western Pacific · 2026Review
- Prevalence of Precursor Lesions in Gastric Adenocarcinoma Specimen: Insights into Pathogenesis in the United States Population.Digestive diseases and sciences · 2026Article
- <italic>Helicobacter pylori</italic>-Naïve Gastric Neoplasms: Clinicopathological and Molecular Features and Diagnostic Challenges.Digestion · 2026Review
- Burden and temporal trends of non-communicable diseases from 1990 to 2021 and prediction to 2035 in the group of twenty countries: a systematic analysis of the Global Burden of Disease Study 2021.Frontiers in microbiology · 2026Article
- Smoking-attributable gastrointestinal cancer burden in Brazil, Russia, India, China and South Africa (BRICS) and Associated Economies: A Global Burden of Disease study analysis 1990Tobacco prevention & cessation · 2026Article
- A Migration-Informed, Risk-Based Approach to H. pylori Screening and Gastric Cancer Prevention in the U.S.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Review
- Gastric Cancer Surgery Before and During the COVID-19 Pandemic in Turkey: A Multicenter Comparison of Prognostic Factors, Mortality, and Survival.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Lymph node metastases in early gastric cancer: Japanese Gastric Cancer Treatment Guidelines can be used for endoscopic resection in the West.Endoscopy international open · 2025Article
- Review
- Gastric metastasis in patients with leiomyosarcoma: A case report.Biomedical reports · 2023Article
- Risk of upper gastrointestinal cancer and death in persons with negative screening results: results from the National Cancer Screening Program in South Korea.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Radiographic and endoscopic screening to reduce gastric cancer mortality: a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2023Article
- Effectiveness of endoscopic screening for gastric cancer: The Japan Public Health Center-based Prospective Study.Cancer science · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Upper gastrointestinal endoscopy for gastric cancer screening has been implemented in Japan. However, its effectiveness for gastric cancer prevention has not been fully studied. We aimed to investigate the effectiveness of endoscopic screening to reduce mortality from gastric cancer. In a large prospective population-based cohort study including 80,272 participants, we compared the risk of mortality and incidence of gastric cancer among participants who underwent endoscopic or radiographic screening compared with those who did not undergo any screening using multivariable Cox proportional hazards models. In the 1,023,364 person-year observation period (median; 13.0 years), 1977 cases of gastric cancer were diagnosed, and 783 patients with gastric cancer died. In the endoscopic screening group, the mortality from gastric cancer and incidence of advanced gastric cancer were reduced by 61% (hazard ratio [HR] = 0.39 [95% CI: 0.30-0.51]) and 22% (HR = 0.78 [95% CI: 0.67-0.90]), respectively. The radiographic screening reduced the mortality from gastric cancer (HR = 0.63 [95% CI: 0.54-0.73]), but its effectiveness was lower than that of endoscopic screening. In conclusion, endoscopic screening reduced the incidence of advanced gastric cancer and mortality from gastric cancer in the Japanese population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.