Evidence map›Paper›PMID 36002073›Full record

Trial reportAmerican journal of ophthalmology2022

Within-Trial Cost-Effectiveness of an Adherence-Enhancing Educational Intervention for Glaucoma.

Andrew M Williams, Christos Theophanous, Kelly W Muir, Jullia A Rosdahl, Sandra Woolson, Maren Olsen, Hayden B Bosworth, Anna Hung

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03052257 (Improving Glaucoma Medication Adherence), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03052257 nacompletednot on this map

Improving Glaucoma Medication Adherence

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2021Enrolled200ConditionsGlaucomaArmsEducational - glaucoma, Dose monitoring and reminder, Educational - general, Dose monitoring
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andrew M WilliamsFrom the Department of Ophthalmology (A.M.W., C.T., K.W.M., J.A.R., H.B.B.), Duke University School of Medicine, Durham, North Carolina, USA; Department of Ophthalmology (A.M.W.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Christos TheophanousFrom the Department of Ophthalmology (A.M.W., C.T., K.W.M., J.A.R., H.B.B.), Duke University School of Medicine, Durham, North Carolina, USA.
Kelly W MuirFrom the Department of Ophthalmology (A.M.W., C.T., K.W.M., J.A.R., H.B.B.), Duke University School of Medicine, Durham, North Carolina, USA; Durham Center of Innovation to Accelerate Discovery and Practice Transformation (K.W.M., S.W., M.O., H.B.B., A.H.), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA. Electronic address: Kelly.muir@duke.edu.
Jullia A RosdahlFrom the Department of Ophthalmology (A.M.W., C.T., K.W.M., J.A.R., H.B.B.), Duke University School of Medicine, Durham, North Carolina, USA.
Sandra WoolsonDurham Center of Innovation to Accelerate Discovery and Practice Transformation (K.W.M., S.W., M.O., H.B.B., A.H.), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.
Maren OlsenDurham Center of Innovation to Accelerate Discovery and Practice Transformation (K.W.M., S.W., M.O., H.B.B., A.H.), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.
Hayden B BosworthFrom the Department of Ophthalmology (A.M.W., C.T., K.W.M., J.A.R., H.B.B.), Duke University School of Medicine, Durham, North Carolina, USA; Durham Center of Innovation to Accelerate Discovery and Practice Transformation (K.W.M., S.W., M.O., H.B.B., A.H.), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.
Anna HungDurham Center of Innovation to Accelerate Discovery and Practice Transformation (K.W.M., S.W., M.O., H.B.B., A.H.), Durham Veterans Affairs Health Care System, Durham, North Carolina, USA; Department of Population Health Sciences (A.H.), Duke University School of Medicine, Durham, NC, United States; Duke-Margolis Center for Health Policy (A.H.), Duke University, Durham, NC, United States.
Duke University · USDurham VA Health Care System · USUniversity of Pittsburgh · US

Funding

Improving Glaucoma Medication AdherenceI01HX001893 · VA · DURHAM VA MEDICAL CENTER · PI MUIR, KELLY · 2018 to 2021
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Helping Veterans Navigate Dual Pharmacy BenefitsIK2HX003359 · VA · DURHAM VA MEDICAL CENTER · PI Anna Hung · 2022 to 2026
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HSRD VA I01 HX001893HSRD VA IK2 HX003359
6 · The paper itself

Abstract

purposeTo assess the within-trial cost-effectiveness of a behavioral intervention to improve glaucoma medication adherence.

designProspective cost-effectiveness analysis of randomized, controlled trial data.

methodsThe study setting was a Veterans Affairs (VA) eye clinic. The patient population comprised veterans with medically treated glaucoma and self-reported poor adherence. Participants were randomized to a personalized educational session with a reminder bottle to promote medication adherence or to a control session on general eye health. Costs were assessed from the perspective of the VA payor at 6 months using the VA Managerial Cost Accounting System. Probabilistic sensitivity analyses were conducted using bootstrapped samples. The main outcome measures were the proportion of participants attaining ≥80% adherence as measured by electronic monitor, total intervention and medical resource costs, and incremental cost-effectiveness ratios comparing intervention to control at 6 months.

resultsOf 200 randomized participants, 95 of 100 assigned to the intervention and 97 of 100 assigned to the control had adherence outcomes at 6 months, and the proportion of adherent patients was higher in the intervention group compared to control (0.78 vs 0.40, P < .0001). All participants had costs at 6 months. The total cost at 6 months was $1,149,600 in the intervention group (n = 100) compared to $1,298,700 in the control group (n = 100). Thus, in a hypothetical cohort of 100 patients, the intervention was associated with cost savings (-$149,100) and resulted in 38 additional patients achieving medication adherence.

conclusionsAn adherence-enhancing behavioral intervention was effective and cost saving at 6 months.

Indexed as

GlaucomaCohort StudiesCost-Benefit AnalysisHumansMedication AdherenceProspective Studies

Identifiers

PMID36002073
PMCPMC10084845
OpenAlexW4292533775

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.