ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023
Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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53 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.European stroke journal · 2026Pooled it
- Similar predictive performance and clinical utility of the Kidney Failure Risk Equation using EKFC or CKD-EPI estimated glomerular filtration rate.Clinical kidney journal · 2026Article
- MERWACS: Development and external validation of a non-invasive machine learning tool for identifying subjects to be screened for CKD.PLOS digital health · 2026Article
- Recalibration of the European Kidney Function Consortium eGFR Equation for the Indian Population.Kidney international reports · 2026Article
- Evaluating Long-Term Outcomes Across eGFR Equations in Older Adults.Kidney international reports · 2026Article
- Performance of creatinine and cystatin C-based equations for estimating high levels of glomerular filtration rate in Congolese adults with sickle cell disease.Clinical kidney journal · 2026Article
- Prevalence of Hyperkalemia in a Contemporary European Cohort According to EKFC eGFR Categories.Diagnostics (Basel, Switzerland) · 2026Article
- Which equation and which biomarker should be used in the Kidney Failure Risk Equation? A comparative analysis in the CKD-REIN cohort.Clinical kidney journal · 2026Article
- Implementing Kidney Disease: Improving Global Outcomes 2024 Through Laboratory-Estimated GFR Across Ages.Kidney international reports · 2026Article
- A Systematic Review Evaluating Estimated GFR Performance in South Asian Populations.Kidney international reports · 2026Article
- Changing from the CKD-EPI to the EKFC creatinine equation to estimate glomerular filtration rate in adults in a Northern European health system.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- The aging-related GFR decline in Chinese healthy elderly.International urology and nephrology · 2026Article
- Combined Creatinine and Cystatin C Equations Improve Estimation of Glomerular Filtration Rate in Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance.Kidney international reports · 2026Article
- Impact of Creatinine-eGFR Equations on Chronic Kidney Disease Stratification in a Ghanaian Tertiary Care Setting.EJIFCC · 2025Article
- When equations disagree: the impact of creatinine-based eGFR in CKD diagnosis and reclassification.BMC nephrology · 2025Article
- Association of glyphosate exposure with kidney function impairment in the adolescents and young adults' population in the U.S. National Health and Nutrition Examination Survey, 2013 to 2016.Paediatrics & child health · 2025Article
- Low Cystatin C-to-Creatinine Estimated GFR Ratio Predicts Post-Kidney Transplant Cardiovascular Events.Kidney international reports · 2025Article
- Novel eGFR equations and cardiovascular outcomes in a multiethnic Asian cohort.Clinical kidney journal · 2025Article
- Comparison of estimated glomerular filtration rate equations on prediction of mortality, kidney failure and acute kidney injury.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
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Authors and funding
39 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundA new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.
methodsStandardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France (n = 4429, including 964 Black Europeans), from Brazil (n = 100) and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed.
resultsIn White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of -0.6 and -3.2, respectively versus 5.0 mL/min/1.73 m², and accuracy within 30% of 86.9 and 87.4, respectively, versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value (= concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males.
conclusionIn a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated population-specific Q-values, presents the best performance in the whole age range in the European and African populations included in this study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.